Results 51 to 60 of about 867,403 (349)

A review of progressive collapse research and regulations [PDF]

open access: yes, 2014
History has demonstrated that buildings designed to conventional design codes can lack the robustness necessary to withstand localised damage, partial or even complete collapse. This variable performance has led governmental organisations to seek ways of
Byfield, M.P.   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Influence of stress states on cleavage fracture in X70 pipeline steels

open access: yesJournal of Pipeline Science and Engineering, 2022
Stress state is a primary factor controlling the ductile fracture behavior of steels, which is typically represented as the combination of the stress triaxiality and Lode angle parameter.
Fuhui Shen   +4 more
doaj   +1 more source

Performance-based optimization of structures: theory and applications [PDF]

open access: yes, 2005
Performance-based Optimization of Structures introduces a method to bridge the gap between optimization theory and its practical applications to structural engineering.
Liang, Qing Quan
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Temperature-dependent deformation and fracture properties of low-carbon martensitic steel in different stress states

open access: yesJournal of Materials Research and Technology, 2023
The temperature-dependent ductile-brittle transition (DBT) in low-carbon martensitic steel is investigated in different stress states. To capture the effects of the stress state, tensile tests have been performed with flat specimens and three-point ...
Zhen Zhang   +4 more
doaj   +1 more source

New structural approach for determining load carrying capability of filament wound composite materials [PDF]

open access: yes, 1970
Metal lined boron and graphite composites exhibit high strength and minimum weight, making them superior to aluminum cylindrical shell structures and to steel or aluminum constructed pressure vessels.
Armstrong, W. H., Yang, P. B.
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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