Results 71 to 80 of about 867,403 (349)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

On the Simplified Numerical Analyses of an Adaptive Double‐Glazed Façade Considering Steady‐State Conditions and Experimental Data

The Journal of Engineering
The façade of a building accounts for large areas of its envelope, representing the interface between the uncontrolled outdoor climate and the conditioned interior. The façade is therefore largely responsible for the building's energy balance.
Henri Paetow, Christin Sirtl, Matthias Kraus   +2 more
doaj   +1 more source

The engineering method for unifying ground floor slab settlements

Engineering Structures and Technologies, 2020
For industrial buildings and logistics centres truck lifts are usually used. Therefore, there are special requirements for flatness tolerance of ground floor. The ground floor settlements differences in selected distances are limited. The article reviews
Kęstutis Urbonas, Danutė Sližytė, Antanas Šapalas   +2 more
doaj   +1 more source

Hydrodynamics of a new concept of primary containment by energy absorption [PDF]

, 1969
Fluid dynamical analysis for idealized reactors system with spherical symmetry determines the effect which the destructive component of a nuclear accident produces on primary containment structures.
Fistedis, S. H., Sorensen, H. C.
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cracks in the charred layer of timber panels: Fire experiments and probabilistic solution

Case Studies in Thermal Engineering
This article presents a calculation method to predict crack evolution in the charred layer of massive timber in the context of fire resistance.
Jakub Šejna, Kristýna Průšová, Kamila Cábová, Simona Rušarová, František Wald   +4 more
doaj   +1 more source

Multiwire submerged arc welding of steel structures [PDF]

, 2012
The assembly of large structures made out of thick steel plates requires a welding process by which multiple wires can be used simultaneously. To reproduce these industrial processes in a research environment, OCAS has invested in a multiwire submerged ...
De Waele, Wim, Dhollander, R, Van Caenegem, Nele, Van Pottelberg, E, Vancauwenberghe, S   +4 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Direct observation of pitting corrosion evolutions on carbon steel surfaces at the nano-to-micro- scales. [PDF]

, 2018
The Cl--induced corrosion of metals and alloys is of relevance to a wide range of engineered materials, structures, and systems. Because of the challenges in studying pitting corrosion in a quantitative and statistically significant manner, its kinetics ...
Balonis, Magdalena, Bauchy, Mathieu, Chen, Xin, Guo, Peng, La Plante, Erika Callagon, Sant, Gaurav, Wang, Bu   +6 more
core   +2 more sources