Results 81 to 90 of about 63,717 (277)

The detailed chemical composition of the terrestrial planet host Kepler-10

, 2015
Chemical abundance studies of the Sun and solar twins have demonstrated that the solar composition of refractory elements is depleted when compared to volatile elements, which could be due to the formation of terrestrial planets.
Asplund, M., Bensby, T., Gustafsson, B., Howes, L. M., Lambert, D. L., Liu, F., Melendez, J., Ramirez, I., Roederer, I. U., Yong, D.   +9 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Cosmic abundances: The impact of stellar duplicity

, 2004
The mass-transfer scenario links chemical peculiarities with stellar duplicity for an increasing number of stellar classes (classical and dwarf barium stars, subgiant and giant CH stars, S stars without technetium, yellow symbiotic stars, WIRRING stars ...
Jorissen, A., Van Eck, S.
core   +1 more source

The minimum stellar metallicity observable in the Galaxy

, 2008
The first stars fundamentally transformed the early Universe through their production of energetic radiation and the first heavy chemical elements. The impact on cosmic evolution sensitively depends on their initial mass function (IMF), which can be ...
Adelman-McCarthy, Anna Frebel, Barkana, Beers, Bondi, Bromm, Bromm, Carollo, Christlieb, Ciardi, Collet, Frebel, Frebel, Frebel, Freeman, Fulbright, Heger, Iben, Iwamoto, Jarrett L. Johnson, Johnson, Johnston, Karlsson, Lacey, Lee, Munn, Norris, Oey, Pagel, Salvadori, Schneider, Talbot, Tumlinson, Umeda, Volker Bromm, Yoshii   +35 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A High-resolution Spectroscopic Survey of Directly Imaged Companion Hosts. II. Diversity in C/O Ratios among Host Stars

The Astronomical Journal
The era of JWST has enabled measurements of abundances of elements such as C, O, and even Na, S, K, and Fe in planetary atmospheres to very high precisions (∼0.1 dex).
Aneesh Baburaj, Quinn M. Konopacky, Christopher A. Theissen, Roman Gerasimov, Kielan K. W. Hoch   +4 more
doaj   +1 more source

The Gaia-ESO Survey: Homogenisation of stellar parameters and elemental abundances [PDF]

, 2023
A. Hourihane, P. François, C. C. Worley, L. Magrini, A. Gonneau, Andrew R. Casey, G. Gilmore, S. Randich, G. G. Sacco, A. Recio-Blanco, A. J. Korn, C. Allende Prieto, R. Smiljanić, R. Blomme, A. Bragaglia, N. A. Walton, S. Van Eck, T. Bensby, A. C. Lanzafame, A. Frasca, E. Franciosini, F. Damiani, K. Lind, M. Bergemann, P. Bonifacio, V. Hill, A. Lobel, D. Montes, D. K. Feuillet, G. Tautvaišienė, G. Guiglion, H. M. Tabernero, J. I. Gónzalez Hernández, M. Gebran, M. Van der Swaelmen, Š. Mikolaitis, S. Daflon, T. Merle, T. Morel, J. R. Lewis, E. A. González Solares, D. N. A. Murphy, R. D. Jeffries, R. J. Jackson, S. Feltzing, T. Prusti, G. Carraro, K. Biazzo, L. Prisinzano, P. Jofré, S. Zaggia, A. Drazdauskas, E. Stonkutė, E. Marfil, F. Jiménez-Esteban, L. Mahy, M. L. Gutiérrez Albarrán, S. R. Berlanas, W. Santos, L. Morbidelli, L. Spina, R. Minkevičiūtė   +61 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Stellar Ancestry Unlocked: Chemical and Orbital Clues Link Metal-poor Stars to Globular Clusters and the Galaxy’s Thick Disk

The Astronomical Journal
This study presents a detailed chemical, kinematic, and orbital dynamic analysis of five metal-poor stars in the solar neighborhood: HD 2665, HD 5916, HD 122956, HD 189349, and HD 218857.
Gizay Yolalan, Timur Şahin, Selçuk Bilir, Olcay Plevne   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source