Results 101 to 110 of about 2,560 (288)

Ram-pressure Stripping of a Kicked Hill Sphere: Prompt Electromagnetic Emission from the Merger of Stellar Mass Black Holes in an AGN Accretion Disk [PDF]

, 2019
B. McKernan, K. E. S. Ford, I. Bartos, M. J. Graham, W. Lyra, S. Marka, Z. Marka, N. P. Ross, D. Stern, Y. Yang   +9 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Tests of Disk-locking in T Tauri Stars of the Orion Nebula Cluster

The Astrophysical Journal
We look for specific correlations predicted by magnetospheric accretion models for young stars that assume disk-locking using stellar and accretion parameters derived from low-resolution HST-STIS spectra of 33 T Tauri stars in the Orion Nebula Cluster ...
Margaret A. Mueller, Christopher M. Johns-Krull, Keivan G. Stassun, Don M. Dixon   +3 more
doaj   +1 more source

Accretion in stellar clusters and the IMF

, 2001
We present a simple physical mechanism that can account for the observed stellar mass spectrum for masses $\ms \simgreat 0.5 \solm$. The model depends solely on the competitive accretion that occurs in stellar clusters where each star's accretion rate depends on the local gas density and the square of the accretion radius.
Bonnell, I. A., Clarke, C. J., Bate, M. R., Pringle, J. E.   +3 more
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Radiation Hydrodynamic Simulations of Massive Stars in Gas-rich Environments: Accretion of AGN Stars Suppressed by Thermal Feedback

The Astrophysical Journal
Massive stars may form in or be captured into active galactic nuclei (AGN) disks. Recent 1D studies employing stellar-evolution codes have demonstrated the potential for rapid growth of such stars through accretion up to a few hundred solar masses.
Yi-Xian Chen, Yan-Fei Jiang, Jeremy Goodman, Douglas N. C. Lin   +3 more
doaj   +1 more source

Hydrodynamic simulations of the inner accretion flow of Sagittarius A* fuelled by stellar winds [PDF]

, 2018
Sean M. Ressler, Eliot Quataert, James M. Stone   +2 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Fifty Years After the Discovery of the First Stellar-Mass Black Hole: A Review of Cyg X-1

Galaxies
Around 50 years ago, the famous bet between Stephen Hawking and Kip Thorne on whether Cyg X-1 hosts a stellar-mass black hole became a well-known story in the history of black hole science.
Jiachen Jiang
doaj   +1 more source

Neutron star accretion in a stellar envelope

The Astrophysical Journal, 1993
Steady spherically symmetric accretion onto a neutron star is possible for a mass accretion rate ˙M≥10 −3 M ○. yr −1 ; the gravitational energy is lost to neutrinos. In the scenario of neutron star spiral-in through a massive stellar envelope, the neutron star accretion rate derived from the Bondi-Hoyle theory is ≥0.2 M ○. yr −1 . Radiation pressure
openaire   +1 more source