Results 121 to 130 of about 2,560 (288)

Component of Energy Flow from Supercritical Accretion Disks Around Rotating Stellar Mass Black Holes

, 2022
Aoto Utsumi, Ken Ohsuga, Hiroyuki R. Takahashi, Yuta Asahina   +3 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Evidence for two early accretion events that built the Milky Way stellar halo [PDF]

, 2019
GyuChul Myeong, Eugene Vasiliev, Giuliano Iorio, N. W. Evans, Vasily Belokurov   +4 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Magnetized Accretion Flows: The Key Roles of Viscosity and Black Hole Mass

The Astrophysical Journal
In our previous work, we constructed a black hole accretion model incorporating magnetic fields and disk winds. However, this model was derived under conditions of a small viscosity parameter α ( α < α _crit , where α _crit is the critical viscosity ...
Wen-Biao Wu
doaj   +1 more source

Radiative accretion shocks along nonuniform stellar magnetic fields in classical T Tauri stars [PDF]

, 2013
S. Orlando, R. Bonito, C. Argiroffi, F. Reale, G. Peres, M. Miceli, T. Matsakos, C. Stehlé, L. Ibgui, L. de Sa, J. P. Chièze, T. Lanz   +11 more
openalex   +1 more source

High Resolution Infrared Spectroscopy of Hot Molecular Gas in AFGL 2591\n and AFGL 2136: Accretion in the Inner Regions of Disks Around Massive Young\n Stellar Objects [PDF]

, 2020
Andrew G. Barr, A. C. A. Boogert, Curtis DeWitt, Edward Montiel, Matthew J. Richter, Thomas Widemann, David A. Neufeld, Nick Indriolo, Y. J. Pendleton, J. E. Chiar, A. G. G. M. Tielens   +10 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Diverse Pathways for Supermassive Black Hole–Galaxy Coevolution

The Astrophysical Journal
Supermassive black holes (SMBHs) are observed in diverse galaxy populations across cosmic time, yet a clear understanding of how they coevolve with their hosts has not been reached.
Bryan A. Terrazas, James Aird, Alison L. Coil   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source