Results 131 to 140 of about 8,281,459 (308)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

TESS Subgiant and Lower-red-giant Asteroseismology in the Continuous Viewing Zones

The Astrophysical Journal
Asteroseismology, the study of stellar oscillations, and stellar modeling both offer profound insights into the fundamental properties and evolution of stars.
Sophia Grusnis, Jamie Tayar, Diego Godoy-Rivera   +2 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Spectroscopic Distance, Mass, and Age Estimations for APOGEE DR17

The Astronomical Journal
We derive distances and masses of stars from the Sloan Digital Sky Survey (SDSS) Apache Point Observatory Galactic Evolution Experiment Data Release 17 using simple neural networks.
Alexander Stone-Martinez, Jon A. Holtzman, Julie Imig, Christian Nitschelm, Keivan G. Stassun, Joel R. Brownstein   +5 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Strength and Variability of the Helium 10830 Å Triplet in Young Stars, with Implications for Exosphere Detection

The Astronomical Journal
Young exoplanets trace planetary evolution, in particular the atmospheric mass loss that is most dynamic in youth. However, the high activity level of young stars can mask or mimic the spectroscopic signals of atmospheric mass loss.
Daniel M. Krolikowski, Adam L. Kraus, Benjamin M. Tofflemire, Caroline V. Morley, Andrew W. Mann, Andrew Vanderburg   +5 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Constraining Stellar Rotation at the Zero-age Main Sequence with TESS

The Astrophysical Journal
The zero-age main sequence (ZAMS) is a critical phase for stellar angular momentum evolution, as stars transition from contraction-dominated spin-up to magnetic wind-dominated spin-down.
S. T. Douglas, P. A. Cargile, S. P. Matt, A. A. Breimann, J. A. Pérez Chávez, C. X. Huang, N. J. Wright, G. Zhou   +7 more
doaj   +1 more source

A tight relation between the age distributions of stellar clusters and the properties of the interstellar medium in the host galaxy [PDF]

, 2017
Meghan Miholics, J. M. Diederik Kruijssen, Alison Sills   +2 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source