Results 131 to 140 of about 95,404 (302)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Constraining Stellar Rotation at the Zero-age Main Sequence with TESS

The Astrophysical Journal
The zero-age main sequence (ZAMS) is a critical phase for stellar angular momentum evolution, as stars transition from contraction-dominated spin-up to magnetic wind-dominated spin-down.
S. T. Douglas, P. A. Cargile, S. P. Matt, A. A. Breimann, J. A. Pérez Chávez, C. X. Huang, N. J. Wright, G. Zhou   +7 more
doaj   +1 more source

Actions Are Weak Stellar Age Indicators in the Milky Way Disk [PDF]

, 2018
Angus Beane, Melissa K Ness, Megan Bedell, Angus Beane, Melissa K Ness, Megan Bedell   +5 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Exploring the Evolution of a Dwarf Spheroidal Galaxy with Smoothed-particle Hydrodynamics Simulations. I. Stellar Feedback

The Astrophysical Journal
A fundamental question regarding the evolution of dwarf spheroidal galaxies is the identification of the key physical mechanisms responsible for gas depletion.
Roberto Hazenfratz, Paramita Barai, Gustavo A. Lanfranchi, Anderson Caproni   +3 more
doaj   +1 more source

Use of Redshifts as Evidence of Dark Energy

Physics
The large-scale dynamics of the universe is generally described in terms of the time-dependent scale factor a(t). To make contact with observational data, the a(t) function needs to be related to the observable z(r) function, redshift versus distance ...
Jan Stenflo
doaj   +1 more source

Stellar magnetism: empirical trends with age and rotation [PDF]

, 2014
A. A. Vidotto, S. G. Gregory, M. Jardine, J.‐F. Donati, P. Petit, J. Morin, C. P. Folsom, J. Bouvier, A. Collier Cameron, G. A. J. Hussain, S. C. Marsden, I. A. Waite, R. Farès, S. V. Jeffers, J. D. do Nascimento   +14 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The Gaia-ESO Survey: open clusters in Gaia-DR1 A way forward to stellar age calibration

, 2018
S. Randich, E. Tognelli, R. J. Jackson, R. D. Jeffries, S. Degl’Innocenti, E. Pancino, P. Re Fiorentin, A. Spagna, G. G. Sacco, A. Bragaglia, L. Magrini, P. G. Prada Moroni, E. J. Alfaro, E. Franciosini, L. Morbidelli, V. Roccatagliata, H. Bouy, Luca Bravi, F. Jiménez-Esteban, C. Jordi, Eleonora Zari, G. Tautvaiśienė, A. Drazdauskas, Š. Mikolaitis, G. Gilmore, S. Feltzing, A. Vallenari, T. Bensby, S. E. Koposov, A. J. Korn, A. C. Lanzafame, R. Smiljanić, A. Bayo, G. Carraro, M. T. Costado, U. Heiter, A. Hourihane, P. Jofré, J. Lewis, L. Monaco, L. Prisinzano, L. Sbordone, S. G. Sousa, C. C. Worley, S. Zaggia   +44 more
openalex   +2 more sources