Results 81 to 90 of about 931,455 (366)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Correlating Intrinsic Stellar Parameters with Mg ii Self-reversal Depths

The Astrophysical Journal
The Mg ii h&k emission lines (2803, 2796 Å) are a useful tool for understanding stellar chromospheres and transition regions due to their intrinsic brightness, relatively low interstellar medium (ISM) absorption interference, and abundance
Anna Taylor, Audrey Dunn, Sarah Peacock, Allison Youngblood, Seth Redfield   +4 more
doaj   +1 more source

Modeling the TESS Light Curve of Ap Si Star MX TrA

Universe
The TESS light curve of the silicon Ap star MX TrA was modeled using the observational surface distribution of silicon, iron, helium, and chromium obtained previously with the Doppler Imaging technique.
Yury Pakhomov, Ilya Potravnov, Anna Romanovskaya, Tatiana Ryabchikova   +3 more
doaj   +1 more source

Bisectors of the HARPS Cross-Correlation-Function. The dependence on stellar atmospheric parameters

, 2011
Bisectors of the HARPS cross-correlation function (CCF) can discern between planetary radial-velocity (RV) signals and spurious RV signals from stellar magnetic activity variations.
Abia, Allen de Prieto, Asplund, Boisse, Bruntt, Cenarro, Croll, da Silva, Dall, Dumusque, Dumusque, D’Odorico, G. Lo Curto, Gonzalez, Gray, Gray, Gray, Gray, Gray, Gustafsson, Gustafsson, Hayek, Hekker, Kupka, Luck, Martínez Fiorenzano, Mayor, McWilliam, Mihalas, Noyes, Piskunov, Povich, Queloz, R. Collet, Ryabchikova, S. O. Selam, Santos, Sousa, Sánchez-Blázquez, T. H. Dall, Toner, Vaughan, Ö. Baştürk   +42 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Validating Solar Atmosphere Models with High-resolution Spectra: The Case of Balmer Lines

The Astrophysical Journal
Stellar and solar atmosphere models are critical tools for numerous astrophysical applications, including the determination of stellar fundamental parameters, the study of stellar dynamos, and the characterization of exoplanetary atmospheres ...
Serena Criscuoli, Adam F. Kowalski, Tyler Case, Odele Coddington   +3 more
doaj   +1 more source

On the sensitivity of extrasolar mass-loss rate ranges: HD 209458b a case study [PDF]

, 2013
We present a 3D hydrodynamic study of the effects that different stellar wind conditions and planetary wind structures have on the calculated Ly-$\alpha$ absorptions produced during the transit of HD 209458b.
Costa, A., D'Angelo, C. S. Villarreal, Esquivel, A., Raga, A., Schneiter, E. M., Velázquez, P.   +5 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Investigation of ρ Cas (HR 9045, HD 224014) stellar atmosphere [PDF]

Serbian Astronomical Journal
The atmosphere of hypergiant ρ Cas is investigated by the method of atmospheric model. Effective temperature and the surface of gravity are determined by comparing the observed and theoretical values of photometrical indices [c1];Q, and ...
Samedov Z.A., Hajieva G.M.
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source