Results 61 to 70 of about 92,482 (301)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Validating Solar Atmosphere Models with High-resolution Spectra: The Case of Balmer Lines

The Astrophysical Journal
Stellar and solar atmosphere models are critical tools for numerous astrophysical applications, including the determination of stellar fundamental parameters, the study of stellar dynamos, and the characterization of exoplanetary atmospheres ...
Serena Criscuoli, Adam F. Kowalski, Tyler Case, Odele Coddington   +3 more
doaj   +1 more source

Parallel Implementation of the PHOENIX Generalized Stellar Atmosphere Program [PDF]

, 1996
We describe the parallel implementation of our generalized stellar atmosphere and NLTE radiative transfer computer program PHOENIX. We discuss the parallel algorithms we have developed for radiative transfer, spectral line opacity, and NLTE opacity and ...
Baron E., E. Baron, France Allard, Peter H. Hauschildt, Rybicki G. B., Schweitzer A.   +5 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigation of ρ Cas (HR 9045, HD 224014) stellar atmosphere [PDF]

Serbian Astronomical Journal
The atmosphere of hypergiant ρ Cas is investigated by the method of atmospheric model. Effective temperature and the surface of gravity are determined by comparing the observed and theoretical values of photometrical indices [c1];Q, and ...
Samedov Z.A., Hajieva G.M.
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Stellar fluxes as probes of convection in stellar atmospheres [PDF]

Proceedings of the International Astronomical Union, 2006
AbstractConvection and turbulence in stellar atmospheres have a significant effect on the emergent flux from late-type stars. The theoretical advancements in convection modelling over recent years have proved challenging for the observers to obtain measurements with sufficient precision and accuracy to allow discrimination between the various ...
openaire   +3 more sources

Infrared Observations During the Secondary Eclipse of HD 209458 b II. Strong Limits on the Infrared Spectrum Near 2.2 Microns

, 2003
We report observations of the transiting extrasolar planet, HD 209458 b, designed to detect the secondary eclipse. We employ the method of `occultation spectroscopy', which searches in combined light (star and planet) for the disappearance and ...
Drake Deming, Jorgensen U. G., L. Jeremy Richardson, Sara Seager, Wittenmyer R. A.   +4 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Stellar magnetic activity – Star-Planet Interactions

EPJ Web of Conferences, 2015
Stellar magnetic activity is an important factor in the formation and evolution of exoplanets. Magnetic phenomena like stellar flares, coronal mass ejections, and high-energy emission affect the exoplanetary atmosphere and its mass loss over time.
Poppenhaeger, K.
doaj   +1 more source