Results 71 to 80 of about 92,482 (301)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Can beating between different dynamo modes explain multiple magnetic cycles in solar - type stars

EPJ Web of Conferences, 2015
Stellar magnetic activity can be characterized by a chaotic, multiple or single cycle behavior. Sometimes cyclic activity can be interrupted by a flat behavior.
Simoniello R., Karoff C., Metcalfe T. S.
doaj   +1 more source

Technetium in Stellar Atmospheres [PDF]

Symposium - International Astronomical Union, 1991
The quantitative determinations of technetium abundances are discussed. Up to now Tc abundances were found for nearly 30 stars which all are thermally pulsing AGB stars. The technetium abundance values for these AGB stars atmospheres, where it was found to be present, cluster around −1.0 ÷ 1.7.
openaire   +1 more source

Temporal Evolution of the Size and Temperature of Betelgeuse's Extended Atmosphere

, 2015
We use the Very Large Array (VLA) in the A configuration with the Pie Town (PT) Very Long Baseline Array (VLBA) antenna to spatially resolve the extended atmosphere of Betelgeuse over multiple epochs at 0.7, 1.3, 2.0, 3.5, and 6.1 cm.
Brown, Alexander, Guinan, Edward F., Harper, Graham M., O'Gorman, Eamon, Richards, Anita M. S., Vlemmings, Wouter, Wasatonic, Richard   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

First JWST/NIRSpec Spectroscopy of O Stars in the Small Magellanic Cloud

The Astrophysical Journal Letters
Determining how much mass is removed by stellar winds is crucial to understanding massive star evolution and feedback. However, traditional spectroscopic diagnostics in the UV and optical are not sensitive enough to characterize weak stellar winds of OB ...
Armin Mang Román, Peter Zeidler, Wolf-Rainer Hamann, Lidia M. Oskinova, M. J. Rickard, S. Reyero Serantes, H. Todt, J. S. Gallagher III, D. Massa, D. Pauli, V. Ramachandran, E. Sabbi, A. A. C. Sander   +12 more
doaj   +1 more source

Evidence for stellar contamination and water absorption in NGTS-5b’s transmission spectra with GTC/OSIRIS

Astronomy & Astrophysics
Context. Transmission spectroscopy serves as a valuable tool for probing atmospheric absorption features in the terminator regions of exoplanets.
Wang Wan-Hao, Chen Guo, Jiang Chengzi, Pallé Enric, Murgas Felipe, Parviainen Hannu   +5 more
doaj   +1 more source

Properties of WNh stars in the Small Magellanic Cloud: evidence for homogeneous evolution

, 2008
We derive the physical properties of three WNh stars in the SMC to constrain stellar evolution beyond the main sequence at low metallicity and to investigate the metallicity dependence of the clumping properties of massive stars.
Bouret, J. C., Depagne, E., Foellmi, C., Hillier, D. J., Marchenko, S., Martins, F., Moffat, A. F.   +6 more
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source