Results 111 to 120 of about 882,024 (358)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Primordial Lithium from Globular Cluster Turnoff Stars: M13 and M71

The Astrophysical Journal
During Big Bang nucleosynthesis (BBN) in the first 15 minutes of the Universe, some ^7 Li was created along with isotopes of H and He. The determination of that primordial value of Li can help constrain the conditions at that time.
Ann Merchant Boesgaard, Constantine P. Deliyannis   +1 more
doaj   +1 more source

3D Hydrodynamical Simulations of Surface Convection in Red Giant Stars. Impact on spectral line formation and abundance analysis

, 2007
We investigate the impact of 3D hydrodynamical model atmospheres of red giant stars at different metallicities on the formation of spectral lines of a number of ions and molecules.
Allende Prieto, Allende Prieto, Allende Prieto, Asplund, Asplund, Asplund, Asplund, Asplund, Asplund, Asplund, Asplund, Barbuy, Barklem, Barklem, Beers, Beers, Bessell, Böhm-Vitense, Canuto, Carlsson, Carney, Cayrel, Christlieb, Christlieb, Collet, Conti, Dravins, Dravins, Dravins, Freytag, Fulbright, García Pérez, Gratton, Grevesse, Gustafsson, Gustafsson, Henyey, Hill, Irwin, Iwamoto, Kiselman, Kiselman, Kiselman, Kurucz, Ludwig, M. Asplund, McWilliam, Meynet, Mihalas, Nissen, Nordlund, Nordlund, R. Collet, R. Trampedach, Ruland, Ryan, Sauval, Schwarzschild, Smith, Spite, Spruit, Steffen, Stein, Storey, Uitenbroek, Vögler, Weiss, Yong   +67 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Technetium in Stellar Atmospheres [PDF]

Symposium - International Astronomical Union, 1991
The quantitative determinations of technetium abundances are discussed. Up to now Tc abundances were found for nearly 30 stars which all are thermally pulsing AGB stars. The technetium abundance values for these AGB stars atmospheres, where it was found to be present, cluster around −1.0 ÷ 1.7.
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Chemical species in Titan's upper atmosphere observed by Cassini/UVIS stellar occultations

, 2022
Siteng Fan, Daniel Zhao, Cheng Li, D. E. Shemansky, Mao‐Chang Liang, Yuk L. Yung   +5 more
openalex   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Influence of Stellar Chromospheres and Coronae on Exoplanet Transmission Spectroscopy

The Astrophysical Journal Letters
A main source of bias in transmission spectroscopy of exoplanet atmospheres is magnetic activity of the host star in the form of stellar spots, faculae, or flares. However, the fact that main-sequence stars have a chromosphere and a corona and that these
Volker Perdelwitz, Adam Chaikin-Lifshitz, Aviv Ofir, Oded Aharonson   +3 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source