Results 101 to 110 of about 43,149 (291)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The Persistent Thermal Anomalies in Rocky Worlds

The Astrophysical Journal
Observing the dayside thermal emissions of rocky exoplanets provides essential insights into their compositions and the presence of atmospheres. Even though no conclusive evidence has been found for atmospheres on small rocky exoplanets orbiting M dwarfs,
Zifan Lin, Tansu Daylan
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Population-level Hypothesis Testing with Rocky Planet Emission Data: A Tentative Trend in the Brightness Temperatures of M-Earths

The Astrophysical Journal
Determining which rocky exoplanets have atmospheres, and why, is a key goal for the James Webb Space Telescope. So far, emission observations of individual rocky exoplanets orbiting M stars (M-Earths) have not provided definitive evidence for atmospheres.
Brandon Park Coy, Jegug Ih, Edwin S. Kite, Daniel D. B. Koll, Moritz Tenthoff, Jacob L. Bean, Megan Weiner Mansfield, Michael Zhang, Qiao Xue, Eliza M.-R. Kempton, Kay Wohlfarth, Renyu Hu, Xintong Lyu, Christian Wöhler   +13 more
doaj   +1 more source

Lithium and boron burning S(E)-factor measurements at astrophysical energies via the Trojan Horse Method

EPJ Web of Conferences, 2014
The residual amount of light elements lithium, beryllium and boron (LiBeB) abundances in stellar atmospheres has been largely accepted as one of the most powerful probes for understanding stellar structure and mixing phenomena. They are in fact gradually
Lamia L., Spitaleri C., Pizzone R. G., Cherubini S., Degl’Innocenti S., Grineviciute J., Gulino M., La Cognata M., Mukhamedzhanov A., Palmerini S., Pappalardo L., Prada Moroni P.G., Puglia S.M.R., Rapisarda G.G., Romano S., Sergi M.L., Tognelli E., Tumino A.   +17 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

The stability of late-type stars close to the Eddington limit [PDF]

, 1997
Super-Eddington luminosities in hydrostatic model atmospheres manifest themselves by the presence of gas pressure inversions. Such inversions are not an artifact of the assumption of hydrostatic equilibrium but can also be present in hydrodynamical model
Asplund, Martin
core   +3 more sources

The Physician‐Scientist Pipeline for Pediatric Rheumatology – Current Landscape and Future Perspectives.

Arthritis Care &Research, Accepted Article.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Pressure in Stellar Atmospheres [PDF]

Nature, 1911
WITHIN the last fifteen years the spectroscopic equipment applied to the study of both laboratory and celestial investigation has been very materially modified both in dispersive power and design. In the early nineties there were very few of the 21.5-feet Rowland concave grating spectrographs in regular commission for terrestrial research, and it is ...
openaire   +1 more source