Results 81 to 90 of about 43,339 (292)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
LINE FORMATION IN SPECTRA OF X-RAY NOVAE
Odessa Astronomical Publications, 2017 Results of X-ray Novae (XN) optical spectra computation are presented. The continuum and Balmer line are calculated. The model of XN as a self-irradiated accretion disk is used.
V. F. Suleimanov, V. V. Shimansky
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Stark Widths of Ar II Spectral Lines in the Atmospheres of Subdwarf B Stars
Atoms, 2017 Stark broadening parameters are of interest for many problems in astrophysics and laboratory plasmas investigation. Ar II spectral lines are observed in many kinds of stellar atmospheres such as the atmospheres of B-Type stars and subdwarf B stars.
Rafik Hamdi +3 more
doaj +1 more source
Absolute Lineshifts - A new diagnostic for stellar hydrodynamics [PDF]
, 2003 For hydrodynamic model atmospheres, absolute lineshifts are becoming an observable diagnostic tool beyond the classical ones of line-strength, -width, -shape, and -asymmetry.
Dravins, Dainis
core +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Primordial Lithium from Globular Cluster Turnoff Stars: M13 and M71
The Astrophysical JournalDuring Big Bang nucleosynthesis (BBN) in the first 15 minutes of the Universe, some ^7 Li was created along with isotopes of H and He. The determination of that primordial value of Li can help constrain the conditions at that time.
Ann Merchant Boesgaard +1 more
doaj +1 more source
, 2018 Most galaxies comparable to or larger than the mass of the Milky Way host hot, X-ray emitting atmospheres, and many such galaxies are radio sources. Hot atmospheres and radio jets and lobes are the ingredients of radio-mechanical active galactic nucleus (
Churazov, E. +3 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source