Results 81 to 90 of about 207,702 (293)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

LINE FORMATION IN SPECTRA OF X-RAY NOVAE

open access: yesOdessa Astronomical Publications, 2017
Results of X-ray Novae (XN) optical spectra computation are presented. The continuum and Balmer line are calculated. The model of XN as a self-irradiated accretion disk is used.
V. F. Suleimanov, V. V. Shimansky
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Limb darkening in spherical stellar atmospheres

open access: yes, 2011
Context. Stellar limb darkening, I(μ = cosθ), is an important constraint for microlensing, eclipsing binary, planetary transit, and interferometric observations, but is generally treated as a parameterized curve, such as ...
H. R. Neilson, J. B. Lester
core   +1 more source

Primordial Lithium from Globular Cluster Turnoff Stars: M13 and M71

open access: yesThe Astrophysical Journal
During Big Bang nucleosynthesis (BBN) in the first 15 minutes of the Universe, some ^7 Li was created along with isotopes of H and He. The determination of that primordial value of Li can help constrain the conditions at that time.
Ann Merchant Boesgaard   +1 more
doaj   +1 more source

Stark Widths of Ar II Spectral Lines in the Atmospheres of Subdwarf B Stars

open access: yesAtoms, 2017
Stark broadening parameters are of interest for many problems in astrophysics and laboratory plasmas investigation. Ar II spectral lines are observed in many kinds of stellar atmospheres such as the atmospheres of B-Type stars and subdwarf B stars.
Rafik Hamdi   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Method for calculating the opacity of the atomic lines in stellar atmospheres

open access: yes, 2009
A new approximate method for calculating the opacity of the atomic lines in the computation of stellar model atmospheres is presented. Transforming the sums in the equation of the opacity of the lines into integrals and considering the Kramers equation ...
OCTAVIO CARDONA NUÑEZ
core  

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