Results 71 to 80 of about 6,001 (306)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Living with a Red Dwarf: X-Ray, UV, and Ca ii Activity–Age Relationships of M Dwarfs
The Astrophysical Journal, 2023 The vast majority of stars in the nearby stellar neighborhood are M dwarfs. Their low masses and luminosities result in slow rates of nuclear evolution and minimal changes to the stars’ observable properties, even along astronomical timescales.
Scott G. Engle
doaj +1 more source
The Application of Mesoturbulence to Stellar Atmospheres [PDF]
International Astronomical Union Colloquium, 1980 AbstractFor realistic stellar atmospheres the equations describing mesoturbulent line formation are solved numerically. The general dependence of theoretical line profiles and equivalent widths on the correlation length 1 and the mean square turbulent velocity a is demonstrated.
openaire +1 more source
The maximum effect of convection in stellar atmospheres on the observed properties of stellar spectra [PDF]
, 1953 In spite of many attempts to solve the problem of convection in stellar atmospheres our present knowledge of its effects on the structure of the outer layers of stars is still inadequate.
Przybylski, Antoni
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Chromospheric Modeling of the Active M3V Star G 80–21 with RH1.5D
The Astrophysical JournalThis study investigates the active regions of the M3.0V star G 80–21 using the observed data from the CARMENES project with synthetic spectra generated by the RH1.5D radiative transfer code.
Shuai Liu +6 more
doaj +1 more source
3D NLTE sodium abundances in late-type stars
Astronomy & AstrophysicsContext. Neutral sodium is an important tracer of the Galactic chemical evolution, a powerful diagnostic of different stellar populations, and the subject of detailed studies of exoplanet atmospheres via transmission spectroscopy. Aims. This work aims to
Canocchi G. +4 more
doaj +1 more source
Molecules in stellar atmospheres [PDF]
, 1998 The effects of molecules on model stellar atmospheres are briefly reviewed. Molecular diagnostics of stellar fundamental parameters and of atmospheric structure are discussed, and the presently emerging "ISO picture" of the outer regions of stars is ...
Gustafsson, Bengt,
core
Spherically symmetric model stellar atmospheres and limb darkening [PDF]
, 2013 Limb darkening is a fundamental ingredient for interpreting observations of planetary transits, eclipsing binaries, optical/infrared interferometry and microlensing events.
H. R. Neilson +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source