Results 71 to 80 of about 215,434 (305)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Living with a Red Dwarf: X-Ray, UV, and Ca ii Activity–Age Relationships of M Dwarfs
The Astrophysical Journal, 2023 The vast majority of stars in the nearby stellar neighborhood are M dwarfs. Their low masses and luminosities result in slow rates of nuclear evolution and minimal changes to the stars’ observable properties, even along astronomical timescales.
Scott G. Engle
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Astronomy & AstrophysicsContext. M dwarfs are key targets for terrestrial exoplanet studies, with prospects for atmospheric spectroscopy. However, strong stellar magnetic activity and frequent flaring require modelling efforts to assess their impact on planetary atmospheres ...
Mamonova E. +6 more
doaj +1 more source
Atomic line broadening by thermal energy fluctuations in stellar atmospheres and plasma diagnostics [PDF]
, 2011 A new method for finding the line widths of atomic lines produced by thermal energy fluctuations in a gaseous system is developed assuming that the atomic linear density change in the energy of the levels is equal to the linear density of the energy ...
OCTAVIO CARDONA NUÑEZ
core
Sodium enrichment of stellar atmospheres
, 2002 48 supergiants and bright giants have been observed in order to investigate the sodium enrichment of their atmospheres and its connection with stellar gravity. We present the equivalent widths of the 6154 Å and 6160 Å $\ion{Na}{i}$ lines measured from
I. A. Egorova +3 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Stellar model atmospheres with abundance stratification [PDF]
, 2009 International audienceContext: Atomic diffusion is believed to be an important physical process in the atmospheres of several types of stars. Stellar atmospheres, including the stratification of the elements due to diffusion, are then needed to properly ...
D. Monin +8 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source