Results 61 to 70 of about 43,149 (291)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Chromospheric Modeling of the Active M3V Star G 80–21 with RH1.5D

The Astrophysical Journal
This study investigates the active regions of the M3.0V star G 80–21 using the observed data from the CARMENES project with synthetic spectra generated by the RH1.5D radiative transfer code.
Shuai Liu, Huigang Wei, Jianrong Shi, Wenxian Li, Henggeng Han, Jifeng Liu, Shangbin Yang   +6 more
doaj   +1 more source

3D NLTE sodium abundances in late-type stars

Astronomy & Astrophysics
Context. Neutral sodium is an important tracer of the Galactic chemical evolution, a powerful diagnostic of different stellar populations, and the subject of detailed studies of exoplanet atmospheres via transmission spectroscopy. Aims. This work aims to
Canocchi G., Wang E. X., Amarsi A. M., Lind K., Racca M.   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

JWST-TST DREAMS: Secondary Atmosphere Constraints for the Habitable Zone Planet TRAPPIST-1 e

The Astrophysical Journal Letters
The TRAPPIST-1 system offers one of the best opportunities to characterize temperate terrestrial planets beyond our own solar system. Within the TRAPPIST-1 system, planet e stands out as highly likely to sustain surface liquid water if it possesses an ...
Ana Glidden, Sukrit Ranjan, Sara Seager, Néstor Espinoza, Ryan J. MacDonald, Natalie H. Allen, Caleb I. Cañas, David Grant, Amélie Gressier, Kevin B. Stevenson, Natasha E. Batalha, Nikole K. Lewis, Douglas Long, Hannah R. Wakeford, Lili Alderson, Ryan C. Challener, Knicole Colón, Jingcheng Huang, Zifan Lin, Dana R. Louie, Elijah Mullens, Kristin S. Sotzen, Jeff A. Valenti, Daniel Valentine, Mark Clampin, C. Matt Mountain, Marshall Perrin, Roeland P. van der Marel   +27 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Coronal Loops with Different Metallicities and Generalized RTV Scaling Laws

The Astrophysical Journal, 2023
Stellar metallicity is a critical factor to characterize the stellar coronae because it directly affects the radiative energy loss from the atmosphere.
Haruka Washinoue, Takeru K. Suzuki
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

LINE FORMATION IN SPECTRA OF X-RAY NOVAE

Odessa Astronomical Publications, 2017
Results of X-ray Novae (XN) optical spectra computation are presented. The continuum and Balmer line are calculated. The model of XN as a self-irradiated accretion disk is used.
V. F. Suleimanov, V. V. Shimansky
doaj   +1 more source