Results 91 to 100 of about 43,149 (291)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The stellar atmosphere simulation code Bifrost

, 2011
Context: Numerical simulations of stellar convection and photospheres have been developed to the point where detailed shapes of observed spectral lines can be explained.
Abbett, Arber, Arnaud, B. V. Gudiksen, Carlsson, Carlsson, Carlsson, Carlsson, Cheung, De Pontieu, DeVore, Dorfi, Galsgaard, Gudiksen, Gustafsson, Hansteen, Hansteen, Hansteen, Hayek, Heggland, Heinemann, Isobe, J. Leenaarts, J. Martínez-Sykora, Keller, Leenaarts, Leenaarts, M. Carlsson, Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Nordlund, Orszag, Rempel, Ryu, Shull, Skartlien, Sod, Stein, Thompson, Tortosa-Andreu, Trujillo Bueno, Tsuji, Tóth, V. H. Hansteen, Vernazza, Vögler, W. Hayek, Wedemeyer-Böhm, Woodall   +49 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

THE EFFECTIVE TEMPERATURE DETERMINATION OF O-B STARS BY H AND He RADIO RECOMBINATION LINES OBSERVATIONS

Odessa Astronomical Publications, 2017
It is proposed to evaluate, on the basis of H and He radio recombination line observations, the number ratio of stellar photons, capable to ionize helium, to those capable to ionize hydrogen.
A. P. Tsivilev
doaj   +1 more source

Cepheid limb darkening, angular diameter corrections, and projection factor from static spherical model stellar atmospheres

, 2012
Context. One challenge for measuring the Hubble constant using Classical Cepheids is the calibration of the Leavitt Law or period-luminosity relationship.
Baade, Barmby, Barnes, Benedict, Bonanos, Burki, C.-C. Ngeow, Claret, Claret, Claret, Clement, Davis, Fouqué, Freedman, Getting, Gieren, Gieren, Gieren, Gray, Groenewegen, H. R. Neilson, Hindsley, J. Storm, Kanbur, Keller, Kervella, Kervella, Kovács, Kurucz, Leavitt, Lester, Marengo, Marengo, Marengo, Marengo, Mourard, Mérand, Mérand, Mérand, N. Nardetto, Nardetto, Nardetto, Nardetto, Nardetto, Neilson, Neilson, Neilson, Neilson, Neilson, Neilson, Ngeow, Ngeow, P. Fouqué, Parsons, Pietrzyński, Riess, Riess, Sabbey, Sasselov, Sasselov, Sasselov, Storm, Storm, Turner, van Leeuwen, Wesselink, Windmark   +66 more
core   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Current status of NLTE analysis of stellar atmospheres

, 2014
Various available codes for NLTE modeling and analysis of hot star spectra are reviewed. Generalizations of standard equations of kinetic equilibrium and their consequences are discussed.Comment: in Determination of Atmospheric Parameters of B-, A-, F ...
A Pauldrach, A Pauldrach, AC Carciofi, AC Carciofi, AE Santolaya-Rey, AWA Pauldrach, D Mihalas, DC Abbott, DJ Hillier, DJ Hillier, DJ Hillier, GB Rybicki, GB Rybicki, GB Rybicki, I Hubeny, I Hubeny, I Hubeny, J Kašparová, J Krtička, J Krtička, J Krtička, J Kubát, J Kubát, J Kubát, J Kubát, J Leenaarts, J Puls, JI Castor, JR Busche, K Werner, KG Gayley, LH Auer, M Carlsson, M Kromer, RP Kudritzki, VP Utrobin, WR Hamann, WR Hamann   +37 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Empirical Prediction of Plasma Emission Measure Distributions and X-Ray/Extreme-ultraviolet Spectra of Late-type Stars

The Astrophysical Journal
High-energy emission spectra from the outer atmospheres of late-type stars represent an important feature of the stellar activity in several contexts, such as the photoevaporation and photochemistry of planetary atmospheres or the modeling of irradiated ...
A. Maggio, I. Pillitteri, J. Sanz-Forcada, G. Micela   +3 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source