Results 91 to 100 of about 215,434 (305)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Gravitational microlensing as a test of stellar model atmospheres [PDF]

, 2002
4 pages, 4 figuresWe present calculations illustrating the potential of gravitational microlensing to discriminate between classical models of stellar surface brightness profiles and the recently computed ``Next Generation\'\' models of Hauschildt et al.
Hendry, M. A., Bryce, H. M., Valls-Gabaud, D.   +2 more
core   +2 more sources

New Theoretical Instability Regions, Period–Luminosity Relations, and Masses for Blue Large-amplitude Pulsators

The Astrophysical Journal
Blue large-amplitude pulsators (BLAPs) are a recently discovered group of hot pulsating stars whose evolutionary status remains uncertain. Their proposed progenitors are either ≃0.3 M _⊙ shell H-burning stars or ≃1.0 M _⊙ core He-burning stars, both ...
Susmita Das, Daniel Jadlovský, László Molnár   +2 more
doaj   +1 more source

Technetium in Stellar Atmospheres [PDF]

Symposium - International Astronomical Union, 1991
The quantitative determinations of technetium abundances are discussed. Up to now Tc abundances were found for nearly 30 stars which all are thermally pulsing AGB stars. The technetium abundance values for these AGB stars atmospheres, where it was found to be present, cluster around −1.0 ÷ 1.7.
openaire   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Physics of Eclipsing Binaries. VI. Hot, Compact Stars

The Astrophysical Journal Supplement Series
Models of eclipsing binaries require the assignment of appropriate emergent intensities to the surface elements of the binary components. For distance-dependent modeling of flux-calibrated light curves, this necessitates an approximation of the absolute ...
David Jones, Nicole Reindl, Kyle E. Conroy, James Munday, Pier-Emmanuel Tremblay, Michael Abdul-Masih, Matthias Fabry, Joseph Giammarco, Kelly M. Hambleton, Herbert Pablo, Marcin Wrona, Andrej Prša   +11 more
doaj   +1 more source

Method for calculating the opacity of the atomic lines in stellar atmospheres

, 2009
A new approximate method for calculating the opacity of the atomic lines in the computation of stellar model atmospheres is presented. Transforming the sums in the equation of the opacity of the lines into integrals and considering the Kramers equation ...
OCTAVIO CARDONA NUÑEZ
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source