Results 111 to 120 of about 43,339 (292)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Microlensing and the Physics of Stellar Atmospheres

, 2000
8 pages including 6 figures. To appear in ``Microlensing 2000: A New Era of Microlensing Astrophysics,'' an ASP conference proceedings, eds. J.W.
openaire   +3 more sources

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

The Persistent Thermal Anomalies in Rocky Worlds

The Astrophysical Journal
Observing the dayside thermal emissions of rocky exoplanets provides essential insights into their compositions and the presence of atmospheres. Even though no conclusive evidence has been found for atmospheres on small rocky exoplanets orbiting M dwarfs,
Zifan Lin, Tansu Daylan
doaj   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Population-level Hypothesis Testing with Rocky Planet Emission Data: A Tentative Trend in the Brightness Temperatures of M-Earths

The Astrophysical Journal
Determining which rocky exoplanets have atmospheres, and why, is a key goal for the James Webb Space Telescope. So far, emission observations of individual rocky exoplanets orbiting M stars (M-Earths) have not provided definitive evidence for atmospheres.
Brandon Park Coy, Jegug Ih, Edwin S. Kite, Daniel D. B. Koll, Moritz Tenthoff, Jacob L. Bean, Megan Weiner Mansfield, Michael Zhang, Qiao Xue, Eliza M.-R. Kempton, Kay Wohlfarth, Renyu Hu, Xintong Lyu, Christian Wöhler   +13 more
doaj   +1 more source

Lithium and boron burning S(E)-factor measurements at astrophysical energies via the Trojan Horse Method

EPJ Web of Conferences, 2014
The residual amount of light elements lithium, beryllium and boron (LiBeB) abundances in stellar atmospheres has been largely accepted as one of the most powerful probes for understanding stellar structure and mixing phenomena. They are in fact gradually
Lamia L., Spitaleri C., Pizzone R. G., Cherubini S., Degl’Innocenti S., Grineviciute J., Gulino M., La Cognata M., Mukhamedzhanov A., Palmerini S., Pappalardo L., Prada Moroni P.G., Puglia S.M.R., Rapisarda G.G., Romano S., Sergi M.L., Tognelli E., Tumino A.   +17 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source