Results 111 to 120 of about 71,994 (275)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Robust Young Stellar Object Identification Method Based on Deep Learning

The Astrophysical Journal Supplement Series
Young stellar objects (YSOs) represent the earliest stage in the process of star formation, offering insights that contribute to the development of models elucidating star formation and evolution.
Lei Tan, Zhicun Liu, Xiaolong Wang, Ying Mei, Feng Wang, Hui Deng, Chao Liu   +6 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

USmorph: An Updated Framework of Automatic Classification of Galaxy Morphologies and Its Application to Galaxies in the COSMOS Field

The Astrophysical Journal Supplement Series
Morphological classification conveys abundant information on the formation, evolution, and environment of galaxies. In this work, we refine a two-step galaxy morphological classification framework ( USmorph ), which employs a combination of unsupervised ...
Jie Song, GuanWen Fang, Shuo Ba, Zesen Lin, Yizhou Gu, Chichun Zhou, Tao Wang, Cai-Na Hao, Guilin Liu, Hongxin Zhang, Yao Yao, Xu Kong   +11 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

FALCO: Foundation Model of Astronomical Light Curves for Time Domain Astronomy. Implementation and Applications on Kepler Data

The Astronomical Journal
Time-domain surveys have advanced astronomical research by revealing diverse variable phenomena, from stellar flares to transient events. The scale and complexity of survey data, along with the demand for rapid classification, present significant ...
Xiaoxiong Zuo, Yihan Tao, Yang Huang, Zhixuan Kang, Huaxi Chen, Chenzhou Cui, Jiashu Pan, Xiao Kong, Yuan-Sen Ting, Xiaoyu Tang, Henggeng Han, Haiyang Mu, Yunfei Xu, Dongwei Fan, Guirong Xue, Ali Luo, Jifeng Liu   +16 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Classification of Wolf–Rayet Stars from LAMOST DR10

The Astrophysical Journal Supplement Series
Wolf–Rayet (WR) stars are highly evolved descendants of the most massive initial stellar populations, serving as essential tracers in stellar evolution. Despite the progress made in their study, a more comprehensive population census is still required to
Jirui Chang, Wenyu Wang, Meixia Qu, Kun Su, Liangping Tu, Chenyang Lv, Bin Jiang, Yanxia Zhang   +7 more
doaj   +1 more source

Commission 45: Stellar Classification: (Classification Stellaire) [PDF]

Transactions of the International Astronomical Union, 2002
Thomas H. H. Lloyd Evans, Christopher Corbally, John Drilling, Sunetra Giridhar, Michèle Gerbaldi, Ted von Hippel, Roberta Humphreys, Xavier Luri, Laura Pasinetti, Vytautas Straižys, Werner Weiss, Kazimeras Zdanavicius   +11 more
openaire   +1 more source