Results 121 to 130 of about 1,941,056 (293)

YOUNG STELLAR OBJECTS IN THE REGION OF DUST BUBBLE N22

Eurasian Physical Technical Journal
The study of young stellar objects is one of the priority areas in modern astrophysics, since these objects serve as key indicators of the processes accompanying the formation of stars and planetary systems.
A.B. Manapbayeva, N.Sh. Alimgazinova, A.Zh. Naurzbaeva, M.T. Kyzgarina, N.E. Abildayev, S.N. Sarsenbayeva, K.M. Turekhanova, A.A. Alibek, A.Zh. Omar, A.M. Demessinova   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Euclid: Quick Data Release (Q1) – Ultracool dwarfs in the Euclid Deep Fields★

Astronomy & Astrophysics
Ultracool dwarfs (UCDs) encompass the lowest-mass stars and brown dwarfs at the stellar–substellar boundary. These intrinsically faint objects are challenging to detect.
Mohandasan A., Smart R. L., Reylé C., Le Brun V., Pérez-Garrido A., Bañados E., Jones H. R. A., Dupuy T., Goldman B., Casewell S. L., Zapatero Osorio M. R., Rejkuba M., Martín E. L., Muñoz Torres S., Domínguez-Tagle C., Žerjal M., Huélamo N., Lodieu N., Cruz P., Majidi F. Z., Rebolo R., Phillips M. W., Zhang J.-Y., Aghanim N., Altieri B., Amara A., Andreon S., Auricchio N., Baccigalupi C., Baldi M., Balestra A., Bardelli S., Battaglia P., Biviano A., Bonchi A., Branchini E., Brescia M., Brinchmann J., Camera S., Cañas-Herrera G., Capobianco V., Carbone C., Carretero J., Casas S., Castellano M., Castignani G., Cavuoti S., Chambers K. C., Cimatti A., Colodro-Conde C., Congedo G., Conselice C. J., Conversi L., Copin Y., Costille A., Courbin F., Courtois H. M., Cropper M., Da Silva A., Degaudenzi H., De Lucia G., Dole H., Douspis M., Dubath F., Dupac X., Dusini S., Escoffier S., Farina M., Faustini F., Ferriol S., Fotopoulou S., Frailis M., Franceschi E., Galeotta S., George K., Gillard W., Gillis B., Giocoli C., Gracia-Carpio J., Granett B. R., Grazian A., Grupp F., Haugan S. V. H., Hoar J., Holmes W., Hook I. M., Hormuth F., Hornstrup A., Jahnke K., Jhabvala M., Keihänen E., Kermiche S., Kiessling A., Kubik B., Kuijken K., Kümmel M., Kunz M., Kurki-Suonio H., Le Boulc’h Q., Le Brun A. M. C., Le Mignant D., Ligori S., Lilje P. B., Lindholm V., Lloro I., Mainetti G., Maino D., Maiorano E., Mansutti O., Marcin S., Marggraf O., Martinelli M., Martinet N., Marulli F., Massey R., Medinaceli E., Mei S., Mellier Y., Meneghetti M., Merlin E., Meylan G., Mora A., Moresco M., Moscardini L., Nakajima R., Neissner C., Niemi S.-M., Padilla C., Paltani S., Pasian F., Pedersen K., Percival W. J., Pettorino V., Pires S., Polenta G., Poncet M., Popa L. A., Pozzetti L., Raison F., Renzi A., Rhodes J., Riccio G., Romelli E., Roncarelli M., Saglia R., Sakr Z., Sapone D., Sartoris B., Schewtschenko J. A., Schirmer M., Schneider P., Schrabback T., Secroun A., Seidel G., Serrano S., Simon P., Sirignano C., Sirri G., Stanco L., Steinwagner J., Surace C., Tallada-Crespí P., Taylor A. N., Tereno I., Toledo-Moreo R., Torradeflot F., Tsyganov A., Tutusaus I., Valenziano L., Valiviita J., Vassallo T., Kleijn G. Verdoes, Veropalumbo A., Vibert D., Wang Y., Weller J., Zacchei A., Zamorani G., Zerbi F. M., Zucca E., Martín-Fleitas J., Scottez V.   +181 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Se-ResNet+SVM Model: An Effective Method of Searching for Hot Subdwarfs from LAMOST

The Astrophysical Journal Supplement Series
This paper presents a robust neural network approach for identifying hot subdwarfs. Our method leveraged the Squeeze-and-Excitation Residual Network to extract abstract features, which were combined with experience features to create hybrid features ...
Zhongding Cheng, Xiaoming Kong, Tianmin Wu, Aina Zhang, Bowen Liu, Yude Bu, Zhenxin Lei, Yatao Zhang, Zhenping Yi, Meng Liu   +9 more
doaj   +1 more source

45. Stellar Classification (Classification Stellaire) [PDF]

Transactions of the International Astronomical Union, 1994
D.J. MacConnel, R.O. Gray, C.B. Stephenson, M.J. Kurtz, J. Rountree, M. Grenon, D. Egret   +6 more
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dusty Stellar Source Classification by Implementing Machine Learning Methods Based on Spectroscopic Observations in the Magellanic Clouds

The Astrophysical Journal
Dusty stellar point sources are a significant stage in stellar evolution and contribute to the metal enrichment of galaxies. These objects can be classified using photometric and spectroscopic observations using color–magnitude diagrams and infrared ...
Sepideh Ghaziasgar, Mahdi Abdollahi, Atefeh Javadi, Jacco Th. van Loon, Iain McDonald, Joana Oliveira, Amirhossein Masoudnezhad, Habib G. Khosroshahi, Bernard H. Foing, Fatemeh Fazel Hesar   +9 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source