Results 121 to 130 of about 2,699,264 (331)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Application of Artificial Neural Networks to Stellar Classification

, 1996
We are working on a project to automate the multi-parameter classification of stellar spectra using Principal Components Analysis (PCA) and Artificial Neural Networks.
Hippel, Ted von, Jones, Coryn A. L., Irwin, Mike   +2 more
core  

FALCO: Foundation Model of Astronomical Light Curves for Time Domain Astronomy. Implementation and Applications on Kepler Data

The Astronomical Journal
Time-domain surveys have advanced astronomical research by revealing diverse variable phenomena, from stellar flares to transient events. The scale and complexity of survey data, along with the demand for rapid classification, present significant ...
Xiaoxiong Zuo, Yihan Tao, Yang Huang, Zhixuan Kang, Huaxi Chen, Chenzhou Cui, Jiashu Pan, Xiao Kong, Yuan-Sen Ting, Xiaoyu Tang, Henggeng Han, Haiyang Mu, Yunfei Xu, Dongwei Fan, Guirong Xue, Ali Luo, Jifeng Liu   +16 more
doaj   +1 more source

Diffraction-driven photometry: A novel method for stellar temperature determination

Astronomy & Astrophysics
Context. Estimating stellar temperatures is a fundamental task in astrophysics, typically achieved using colour indices (CI) derived from multi-filter photometry.
Bonaque-González Sergio, Ríos-Rodríguez Susana, de Varona Omar, Martín-Rodríguez Leopoldo L., Molina Pablo   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Classification of Wolf–Rayet Stars from LAMOST DR10

The Astrophysical Journal Supplement Series
Wolf–Rayet (WR) stars are highly evolved descendants of the most massive initial stellar populations, serving as essential tracers in stellar evolution. Despite the progress made in their study, a more comprehensive population census is still required to
Jirui Chang, Wenyu Wang, Meixia Qu, Kun Su, Liangping Tu, Chenyang Lv, Bin Jiang, Yanxia Zhang   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

2.1-MU-M IMAGES OF THE EVOLVED STELLAR DISK AND THE MORPHOLOGICAL CLASSIFICATION OF SPIRAL GALAXIES

, 1994
Near-infrared images confirm that the Hubble classification of spiral galaxies does not constrain the morphology of their stellar Population H disk, since galaxies on opposite ends of the spiral sequence can display remarkably similar evolved disk ...
STOCKTON, A, GROSBOL, P, MOORWOOD, AFM, BLOCK, DL, BERTIN, G, PELETIER, RF   +5 more
core   +1 more source

USmorph: An Updated Framework of Automatic Classification of Galaxy Morphologies and Its Application to Galaxies in the COSMOS Field

The Astrophysical Journal Supplement Series
Morphological classification conveys abundant information on the formation, evolution, and environment of galaxies. In this work, we refine a two-step galaxy morphological classification framework ( USmorph ), which employs a combination of unsupervised ...
Jie Song, GuanWen Fang, Shuo Ba, Zesen Lin, Yizhou Gu, Chichun Zhou, Tao Wang, Cai-Na Hao, Guilin Liu, Hongxin Zhang, Yao Yao, Xu Kong   +11 more
doaj   +1 more source