Results 121 to 130 of about 71,994 (275)

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Dusty Stellar Source Classification by Implementing Machine Learning Methods Based on Spectroscopic Observations in the Magellanic Clouds

The Astrophysical Journal
Dusty stellar point sources are a significant stage in stellar evolution and contribute to the metal enrichment of galaxies. These objects can be classified using photometric and spectroscopic observations using color–magnitude diagrams and infrared ...
Sepideh Ghaziasgar, Mahdi Abdollahi, Atefeh Javadi, Jacco Th. van Loon, Iain McDonald, Joana Oliveira, Amirhossein Masoudnezhad, Habib G. Khosroshahi, Bernard H. Foing, Fatemeh Fazel Hesar   +9 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Red Stellar Populations and Dust Extinction toward W3

The Astrophysical Journal
We explore red stellar populations toward the W3 giant molecular cloud through the use of optical-to-infrared (IR) photometry and Gaia DR 3 data, simultaneously characterizing stellar content and properties of dust in the molecular medium.
J. L. Campbell, P. G. Martin, S. Song, M. Rahman, L. Einstein   +4 more
doaj   +1 more source

Analysis of Habitability and Stellar Habitable Zones from Observed Exoplanets

Galaxies
The investigation of exoplanetary habitability is integral to advancing our knowledge of extraterrestrial life potential and detailing the environmental conditions of distant worlds. In this analysis, we explore the properties of exoplanets situated with
Jonathan H. Jiang, Philip E. Rosen, Christina X. Liu, Qianzhuang Wen, Yanbei Chen   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Se-ResNet+SVM Model: An Effective Method of Searching for Hot Subdwarfs from LAMOST

The Astrophysical Journal Supplement Series
This paper presents a robust neural network approach for identifying hot subdwarfs. Our method leveraged the Squeeze-and-Excitation Residual Network to extract abstract features, which were combined with experience features to create hybrid features ...
Zhongding Cheng, Xiaoming Kong, Tianmin Wu, Aina Zhang, Bowen Liu, Yude Bu, Zhenxin Lei, Yatao Zhang, Zhenping Yi, Meng Liu   +9 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Characterising the post-red supergiant binary system AFGL 4106 and its complex nebula with SPHERE/VLT

Astronomy & Astrophysics
Context. Mass loss in evolved massive stars plays a critical role in shaping their circumstellar environments and enriching the interstellar medium. In binary systems, stellar interactions can further complicate this process, affecting stellar evolution,
Tomassini G., Lagadec E., El Mellah I., Oudmaijer R. D., Chiavassa A., N’Diaye M., de Laverny P., Nardetto N., Matter A.   +8 more
doaj   +1 more source