Results 121 to 130 of about 210,777 (318)

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

open access: yesMolecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian   +12 more
wiley   +1 more source

Galaxy Quenching at the High Redshift Frontier: A Fundamental Test of Cosmological Models in the Early Universe with JWST-CEERS

open access: yesThe Astrophysical Journal
We present an analysis of the quenching of star formation in massive galaxies ( M _* > 10 ^9.5 M _⊙ ) within the first 0.5–3 Gyr of the Universe’s history utilizing JWST-CEERS data.
Asa F. L. Bluck   +12 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

The Evaporating Massive Embedded Stellar Cluster IRS 13 Close to Sgr A*. II. Kinematic Structure

open access: yesThe Astrophysical Journal
The existence of two distinct and apparently unrelated populations of dusty stellar objects in the Nuclear Stellar Cluster of the Milky Way, namely IRS 13 and the S-cluster, are potentially prone to a general process describing the star formation history
Florian Peißker   +10 more
doaj   +1 more source

Machine Learning Classification of Young Stellar Objects and Evolved Stars in the Magellanic Clouds Using the Probabilistic Random Forest Classifier [PDF]

open access: yes
The Magellanic Clouds (MCs) are excellent locations to study stellar dust emission and its contribution to galaxy evolution. Through spectral and photometric classification, MCs can serve as a unique environment for studying stellar evolution and galaxies enriched by dusty stellar point sources.
arxiv   +1 more source

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