Results 131 to 140 of about 2,400,614 (354)

OB stars at the lowest Local Group metallicity: GTC-OSIRIS observations of Sextans A

open access: yes, 2015
Our aim is to find and classify OB stars in Sextans A, to later determine accurate stellar parameters of these blue massive stars in this low metallicity region $(Z \sim 0.1 \rm Z_{\odot})$.
Camacho, I.   +3 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Analysis of Habitability and Stellar Habitable Zones from Observed Exoplanets

open access: yesGalaxies
The investigation of exoplanetary habitability is integral to advancing our knowledge of extraterrestrial life potential and detailing the environmental conditions of distant worlds. In this analysis, we explore the properties of exoplanets situated with
Jonathan H. Jiang   +4 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Se-ResNet+SVM Model: An Effective Method of Searching for Hot Subdwarfs from LAMOST

open access: yesThe Astrophysical Journal Supplement Series
This paper presents a robust neural network approach for identifying hot subdwarfs. Our method leveraged the Squeeze-and-Excitation Residual Network to extract abstract features, which were combined with experience features to create hybrid features ...
Zhongding Cheng   +9 more
doaj   +1 more source

Equivalent width Measurements in Optical Spectra of Galaxies in Local Clusters: Hints On the Star Formation History in Clusters

open access: yesOpen Astronomy, 2011
Equivalent widths of spectral lines in the optical spectra of galaxies are commonly used to characterize their stellar populations and to get some insight on their evolution.
Fritz Jacopo   +3 more
doaj   +1 more source

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