Results 121 to 130 of about 3,161,922 (291)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synthetic clusters of massive stars to test stellar evolution models

, 2017
During the last few years, the Geneva stellar evolution group has released new grids of stellar models, including the effect of rotation and with updated physical inputs (Ekström et al . 2012; Georgy et al . 2013a, b).
Ekström, Sylvia, Georgy, Cyril
core   +1 more source

Tracing the History of Obscured Star Formation with the SIMBA Cosmological Galaxy Evolution Simulation

The Astrophysical Journal
We explore the cosmic evolution of the fraction of dust-obscured star formation predicted by the simba cosmological hydrodynamic simulations featuring an on-the-fly model for dust formation, evolution, and destruction.
Dhruv T. Zimmerman, Desika Narayanan, Katherine E. Whitaker, Romeel Davé   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Correlations between Ca ii H and K Emission and the Gaia M Dwarf Gap

The Astrophysical Journal
The Gaia M dwarf gap, also known as the Jao Gap, is a novel feature discovered in the Gaia Data Release 2 G versus BP-RP color–magnitude diagram. This gap represents a 17% decrease in stellar density in a thin magnitude band around the convective ...
Emily M. Boudreaux, Aylin Garcia Soto, Brian C. Chaboyer   +2 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Observations of the Halo Star HD 177566

The Astrophysical Journal
We have analyzed archival far-ultraviolet (FUV) and optical spectra of the hot halo star HD 177566. The star has an effective temperature T _eff = 33,000 ± 1000 K, surface gravity $\mathrm{log}g=3.79\pm 0.11$ , and helium abundance $\mathrm{log}N({\rm{He}
William V. Dixon, Pierre Chayer
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The YREC Stellar Evolution Code: Public Data Release

The Astrophysical Journal
In this paper we present the public release of the Yale Rotating Evolution Code (YREC). YREC is a stellar evolution code that covers brown dwarfs and stars across a wide range of masses, and evolutionary states from the pre-main sequence through helium ...
Marc H. Pinsonneault, Jennifer L. van Saders, Lyra Cao, Jamie Tayar, Franck Delahaye, Leslie M. Morales, Rachel A. Patton, Matthew C. Rendina, Joel C. Zinn, Zachary R. Claytor, Amanda L. Ash, Susan Byrom, Kaili Cao, Vincent A. Smedile   +13 more
doaj   +1 more source