Results 71 to 80 of about 4,904 (241)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Calibrated stellar models for metal-poor populations
, 2004 We extend to lower metallicities recent evolutionary computations devoted to Magellanic Clouds stars, presenting and discussing new stellar models with Z = 0.0002, 0.0004, 0.0006, 0.001 and suitable assumptions about the original He content.
Castellani V. +5 more
core +1 more source
Evolutionary Population Synthesis in Stellar Systems. II. Early-Type Galaxies [PDF]
, 1995 In this work we present an articulated analysis addressing the general problem of the present evolutionary status of early-type galaxies (ETGs). This relies on the original approach to stellar evolutionary population synthesis developed in Buzzoni(1989).
BUZZONI, Alberto
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Predicting photospheric UV emission from stellar evolutionary models
Stellar ultraviolet (UV) emission serves as a crucial indicator for estimating magnetic activity and evaluating the habitability of exoplanets orbiting stars. In this paper, we present a straightforward method to derive stellar photospheric UV emission for F to M main-sequence stars.
Wang, Song +3 more
openaire +2 more sources
The Astrophysical Journal Supplement Series, 1991 Stellar evolution with parameterized overshooting from the convective core has been studied for the stellar mass range M/M(solar) = 3-30 and for the initial chemical composition range Xe = 0.650-0.739 (hydrogen) and Ze = 0.021-0.044 (metals). Evolutionary sequences run from the zero-age main sequence to the end of core helium burning, but emphasis is ...
Chao-Wen Chin, Richard B. Stothers
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Stellar population models in the Near-Infrared [PDF]
, 2015 The study of early-type elliptical and lenticular galaxies provides important information about the formation and evolution of galaxies in the early Universe.
Meneses-Goytia, Sofia
core +3 more sources
Evolutionary models for ultracool dwarfs : implications for the Trappist-1 star [PDF]
, 2019 Ultra-cool dwarfs are excellent targets when searching for eclipsing earth-like exoplanets. The signature of a transit carries the information about the system dynamics and the physical properties of the exoplanet with respect with its host-star ...
Burgasser, Adam +7 more
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