Results 91 to 100 of about 1,638 (254)

On Convective Turnover Times and Dynamos in Low-mass Stars

The Astrophysical Journal
The relationship between magnetic activity and Rossby number is one way through which stellar dynamos can be understood. Using measured rotation rates and X-ray to bolometric luminosity ratios of an ensemble of stars, we derive empirical convective ...
Seth Gossage, Rocio Kiman, Kristina Monsch, Amber A. Medina, Jeremy J. Drake, Cecilia Garraffo, Yuxi(Lucy) Lu, Joshua D. Wing, Nicholas J. Wright   +8 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

FASTAR -- I. Continuous and differentiable evolutionary stellar population models

14 pages, 18 figures.
Martín-Navarro, Ignacio, Vazdekis, Alexandre, de Arriba, Luis Peralta, Asensio, Isaac Alonso, Angeloudi, Eirini, Navarro, Patricia Iglesias, La Barbera, Francesco, Fahrion, Katja, Jerabkova, Tereza, Beasley, Michael A., Falcón-Barroso, Jesús, Huertas-Company, Marc, Sánchez, Sebastián F., Jethwa, Prashin   +13 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Effect of Matter Accretion on Lithium Enhancement of Giants

The Astrophysical Journal
A subset of low-mass giants (
Xue-Feng Li, Jian-Rong Shi, Yan Li, Hong-Liang Yan, Jing-Hua Zhang, Fei Guo   +5 more
doaj   +1 more source

CHRONOS: Towards a self-consistent and absolute stellar age scale

Astronomy & Astrophysics
Context. Establishing a self-consistent age scale for stellar populations requires physically well-calibrated chronometers. Among these, lithium-based diagnostics, particularly the lithium depletion boundary (LDB), provide one of the most robust age ...
González-Ramírez L., Barrado D., Olivares J., Berihuete A., Sarro L. M., Palmero F. J.   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Asteroseismic Inversions for Internal Sound Speed Profiles of Main-sequence Stars with Radiative Cores

The Astrophysical Journal
The theoretical oscillation frequencies of even the best asteroseismic models of solar-like oscillators show significant differences from observed oscillation frequencies.
Lynn Buchele, Earl P. Bellinger, Saskia Hekker, Sarbani Basu, Warrick Ball, Jørgen Christensen-Dalsgaard   +5 more
doaj   +1 more source