Results 111 to 120 of about 1,638 (254)

Stellar Evolution in Real Time. II. R Hydrae and an Open-Source Grid of >3000 Seismic TP-AGB Models Computed with MESA

The Astrophysical Journal
We present a comprehensive characterization of the evolved thermally pulsing asymptotic giant branch (TP-AGB) star R Hydrae (R Hya), building on the techniques applied in Stellar Evolution in Real Time I (Molnár et al.) to T Ursae Minoris.
Meridith Joyce, László Molnár, Giulia Cinquegrana, Amanda Karakas, Jamie Tayar, Dóra Tarczay-Nehéz   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Pulsational Mass Loss from Supermassive Stars Creates the Compact Shells of Little Red Dots

The Astrophysical Journal Letters
Little Red Dots (LRDs) have emerged as one of the central puzzles of the JWST era. Their spectra increasingly require dense gas close to the source, yet the physical origin of that cocoon-like structure remains unclear.
Devesh Nandal, Igor V. Chilingarian, Chris Nagele, John Chisholm, Franz E. Bauer, Abraham Loeb   +5 more
doaj   +1 more source

The Effects of Stellar Wind, Rotation Velocity, and Overshoot Parameters on The Evolution of Massive Stars using MESA: Case Study of MPG 324, MPG 355, MPG 682

Spektra: Jurnal Fisika dan Aplikasinya
Massive stars (over 8 solar masses) undergo intricate cosmic journeys. Their evolution, shaped by parameters like stellar wind, rotation velocity, and overshoot, generally includes the pre-main sequence, main sequence, and post-main sequence phases.
Alin Hafizhah Adira, Aprilia
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Evidence that Mass Loss on the Red Giant Branch Decreases with Metallicity

The Astrophysical Journal
Mass loss on the red giant branch (RGB) influences stellar evolution, properties of stellar populations, and Galactic chemical enrichment, yet remains poorly constrained observationally. Current models provide limited insight into how stellar properties,
Yaguang Li
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source