Results 131 to 140 of about 69,893 (289)

Older Ages for 23 Pre-main Sequence Stars in Upper Scorpius Using Dynamical-mass-constrained Stellar Evolutionary Models

The Astrophysical Journal
We present revised stellar ages for 23 pre-main-sequence (PMS) K- and M-type stars in the Upper Scorpius (Upper Sco) star-forming region, derived using stellar dynamical masses to constrain isochronal ages from five PMS stellar evolutionary models.
A. P. M. Towner, J. A. Eisner, P. D. Sheehan, L. A. Hillenbrand, Y.-L. Wu   +4 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Stellar evolutionary models from the zero-age main sequence to the first thermal pulse

The Astrophysical Journal Supplement Series, 1991
Detailed numerical tabulations of 32 stellar evolutionary sequences extending from either the zero-age main sequence (ZAMS) or the zero-age horizontal branch (ZAHB), and through to the occurrence of thermal pulses on the asymptotic giant branch, are presented. The models span a range of 1-3 M ○. (except for one 4 M ○. and one 5 M ○. model) and cover
openaire   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Solar-like Oscillations in Accreting Pre-main-sequence Stars: Insights and Prospects

The Astrophysical Journal
We present theoretical predictions for solar-like oscillators in the pre-main-sequence (pre-MS) phase of stellar evolution. Our pre-MS models start from a stellar seed of 0.01 solar masses that gains mass through accretion, offering an alternative ...
Johannes Jørgensen, Konstanze Zwintz, Ebraheem Farag, Eduard I. Vorobyov, Thomas Steindl   +4 more
doaj   +1 more source

Effect of binary stars on the dynamical evolution of stellar clusters. II - Analytic evolutionary models

The Astronomical Journal, 1975
We use analytic models to compute the evolution of the core of a stellar system due simultaneously to stellar evaporation which causes the system (core) to contract and to its binaries which cause it to expand by progressively decreasing its binding energy.
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Predicting photospheric UV emission from stellar evolutionary models

Stellar ultraviolet (UV) emission serves as a crucial indicator for estimating magnetic activity and evaluating the habitability of exoplanets orbiting stars. In this paper, we present a straightforward method to derive stellar photospheric UV emission for F to M main-sequence stars.
Wang, Song, Li, Xue, Han, Henggeng, Liu, Jifeng   +3 more
openaire   +1 more source