Results 131 to 140 of about 7,730,975 (288)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Evolutionary models for ultracool dwarfs : implications for the Trappist-1 star [PDF]

, 2019
Ultra-cool dwarfs are excellent targets when searching for eclipsing earth-like exoplanets. The signature of a transit carries the information about the system dynamics and the physical properties of the exoplanet with respect with its host-star ...
Burgasser, Adam, Aringer, Bernhard, Salmon, Sébastien, Silva Fernandes, Catarina, Fontaine, Gilles, Van Grootel, Valérie, Scuflaire, Richard, Brassard, Pierre   +7 more
core  

TOPoS

Astronomy & Astrophysics
Context. One technique for determining stellar ages is to compare the position of a star in the Hertzsprung-Russell diagram to theoretical stellar evolutionary tracks.
Bonifacio P., Lebreton Y., Koutsouridou I., Zou Y. P., Romano D., Salvadori S., Sbordone L., Monaco L., Caffau E., Spite M., François P.   +10 more
doaj   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Chemically Self-consistent Modeling of the Globular Cluster NGC 2808 and its Effects on the Inferred Helium Abundance of Multiple Stellar Populations

The Astrophysical Journal
The helium abundances in the multiple populations that are now known to comprise all closely studied Milky Way globular clusters (GCs) are often inferred by fitting isochrones generated from stellar evolutionary models to GC photometry.
Emily M. Boudreaux, Brian C. Chaboyer, Amanda Ash, Renata Edaes Hoh, Gregory Feiden   +4 more
doaj   +1 more source

MESAlab: A python pipeline for Mesa grid processing with integrated GYRE/Mesa-RSP execution

SoftwareX
Modules for Experiments in Stellar Astrophysics ( MESA ) is a widely used open-source code for modeling stellar evolution. Many applications of the code rely on large computational grids containing thousands of models, which can be time-consuming to ...
D. Tarczay-Nehéz
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Calibrated stellar models for metal-poor populations

, 2004
We extend to lower metallicities recent evolutionary computations devoted to Magellanic Clouds stars, presenting and discussing new stellar models with Z = 0.0002, 0.0004, 0.0006, 0.001 and suitable assumptions about the original He content.
Castellani V., Cariulo P, DEGL'INNOCENTI, SCILLA, P. Cariulo, S. Degl'Innocenti, V. Castellani   +5 more
core   +1 more source

A Classical Cepheid in a LMC eclipsing binary: evidence of shortcomings in current stellar evolutionary models?

, 2011
The recent discovery and analysis of a classical Cepheid in the well detached, double-lined, eclipsing binary OGLE-LMC-CEP0227, has provided the first determination of the dynamical mass of a classical Cepheid variable to an unprecedented 1% accuracy. We show here that modern stellar evolution models widely employed to study Galactic and extragalactic ...
Cassisi, Santi, Salaris, Maurizio
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source