Results 121 to 130 of about 7,730,975 (288)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

The BONNSAI Project: A Statistical Comparison of Stars with Stellar Evolution Models

, 2014
We present a Bayesian method that simultaneously takes all available observables for a given star, their uncertainties and prior knowledge like the initial mass function into account to determine probability distributions of the stellar parameters based ...
F.R.N. Schneider, H.H.B. Lau, N. Langer, R.G. Izzard   +3 more
core   +1 more source

Stellar population gradients in galaxy discs from the CALIFA survey : the influence of bars [PDF]

, 2014
We acknowledge financial support from the research projects under grants AYA2010-21887-C04-03, AYA2010-21322-C03-03 and AYA2010-15081 by the Spanish Ministerio de Ciencia e Innovación.While studies of gas-phase metallicity gradients in disc galaxies are ...
Wisotzki, L., S. Zibetti, Márquez, I., D. Mast, Papaderos, P., R. García Benito, Rosales-Ortega, F.F., Sánchez, S. F., I. Pérez, Sánchez, S.F., J. Falcón-Barroso, Ruiz Lara, T., P. Sánchez-Blázquez, R. Cid Fernandes, L. Wisotzki, G. van de Ven, de Lorenzo Cáceres, A., P. Papaderos, C. Catalán-Torrecilla, M. Mollá, González Delgado, R., Mendoza, M. A., Aguerri, J.A.L., F. F. Rosales-Ortega, Mendez Abreu, Jairo, Ruiz-Lara, T., Cid Fernandes, R., A. de Lorenzo-Caceres, J. Méndez-Abreu, Zibetti, S., T. Ruiz-Lara, Mendoza, M.A., Iglesias Paramo, Jorge, B. Husemann, Sánchez Blázquez, Patricia, Falcón Barroso, J., Bland-Hawthorn, J., M. A. Mendoza, B. Jungwiert, Catalán Torrecilla, Cristina, Mollá, M., A. Galazzi, C. J. Walcher, A. Gil de Paz, Rosales Ortega, F. F., Mast, D., Marino, Raffaella Anna, Husemann, B., De Amorim, A., J. A. L. Aguerri, Aguerri, J. A. L., Gil De Paz, Armando, Marino, R.A., J. Bland-Hawthorn, A. de Amorim, Pérez, I., R. A. Marino, Walcher, C. J., Méndez Abreu, J., I. Márquez, Walcher, C.J., Galazzi, A., Iglesias-Páramo, J., Jungwiert, B., S. F. Sánchez, R. González Delgado, De Lorenzo-Caceres Rodriguez, Adriana, Catalán-Torrecilla, C., Gil De Paz, A., Van De Ven, G., Falcón-Barroso, J., García Benito, R., Sánchez-Blázquez, P., Jorge Iglesias-Páramo   +73 more
core   +1 more source

Evolutionary stellar models for multiple population Globular Clusters: theoretical framework and interpretative analysis [PDF]

We briefly summarize the impact of the chemical peculiarities associated to the multiple population phenomenon in Galactic Globular Clusters, on the evolutionary properties and spectral energy distribution of second generation stars, in comparison with ...
Cassisi, S, Pietrinferni, A, Salaris, M
core   +3 more sources

Asteroseismic Inversions for Internal Sound Speed Profiles of Main-sequence Stars with Radiative Cores

The Astrophysical Journal
The theoretical oscillation frequencies of even the best asteroseismic models of solar-like oscillators show significant differences from observed oscillation frequencies.
Lynn Buchele, Earl P. Bellinger, Saskia Hekker, Sarbani Basu, Warrick Ball, Jørgen Christensen-Dalsgaard   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The nature and origin of disky elliptical galaxies [PDF]

, 2002
The observational trend that disky elliptical galaxies exhibit younger luminosity- weighted ages than boxy ellipticals is investigated. The presence of a possible young stellar disk embedded in these galaxies is explored by comparing kinematics derived ...
McDermid, Richard Morgan
core  

Beyond MESA Defaults: The Impact of Structural Resolution Uncertainty in p-mode Asteroseismology

The Astrophysical Journal
Observations of pressure modes ( p -modes) in stars have enabled profound insights into stellar properties, and theoretical stellar evolution and oscillation models are integral to these inferences.
Yaguang Li, Meridith Joyce
doaj   +1 more source