Results 101 to 110 of about 69,893 (289)

Comparative studies of Population Synthesis Models in the frame work of modified Str\"{o}mgren filters

, 2014
Evolutionary models form a vital part of stellar population research to understand their evolution, but despite their long history of development, they often misrepresent and misinterpret the properties of stellar population observed through broadband ...
Hensler, Gerhard, Rakos, Karl, Sreedhar, Yuvraj Harsha   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of Matter Accretion on Lithium Enhancement of Giants

The Astrophysical Journal
A subset of low-mass giants (
Xue-Feng Li, Jian-Rong Shi, Yan Li, Hong-Liang Yan, Jing-Hua Zhang, Fei Guo   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Asteroseismic Inversions for Internal Sound Speed Profiles of Main-sequence Stars with Radiative Cores

The Astrophysical Journal
The theoretical oscillation frequencies of even the best asteroseismic models of solar-like oscillators show significant differences from observed oscillation frequencies.
Lynn Buchele, Earl P. Bellinger, Saskia Hekker, Sarbani Basu, Warrick Ball, Jørgen Christensen-Dalsgaard   +5 more
doaj   +1 more source

Model-independent measurement of internal stellar structure in 16 Cygni A and B

, 2017
We present a method for measuring internal stellar structure based on asteroseismology that we call "inversions for agreement." The method accounts for imprecise estimates of stellar mass and radius as well as the relatively limited oscillation mode sets
Ball, Warrick H., Basu, Sarbani, Bellinger, Earl P., Hekker, Saskia   +3 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Calibrated stellar models for metal-poor population

, 2004
We extend to lower metallicities recent evolutionary computations devoted to Magellanic Clouds stars, presenting and discussing new stellar models with Z=0.0002, 0.0004, 0.0006, 0.001 and suitable assumptions about the original He content.
Alexander, Angulo, Bahcall, Barbaro, Bertelli, Bertelli, Bono, Brocato, Brocato, Brocato, Canuto, Carraro, Carretta, Carretta, Cassisi, Cassisi, Cassisi, Cassisi, Castellani, Castellani, Castellani, Castellani, Castellani, Castellani, Castellani, Castelli, Castelli, Caughlan, Chaboyer, Chaboyer, Chabrier, Ciacio, Degl'Innocenti, Dominguez, Ferraro, Gallart, Girardi, Girardi, Gratton, Haft, Harris, Hubbard, Iglesias, Itoh, Itoh, Itoh, Kraft, Lejeune, Maeder, Mateo, Mihalas, Monelli, Mowlavi, Munakata, P. Cariulo, Pagel, Palacios, Rey, Richard, Richer, Rogers, Rogers, Rood, Rutledge, S. Degl'Innocenti, Salaris, Salaris, Salaris, Salaris, Salaris, Salasnich, Schaller, Stetson, Straniero, Straniero, Suntzeff, Thoul, V. Castellani, VandenBerg, VandenBerg, VandenBergh, Walker, Woo, Yi, Zinn, Zinn   +85 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source