Results 101 to 110 of about 1,638 (254)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Beyond MESA Defaults: The Impact of Structural Resolution Uncertainty in p-mode Asteroseismology

The Astrophysical Journal
Observations of pressure modes ( p -modes) in stars have enabled profound insights into stellar properties, and theoretical stellar evolution and oscillation models are integral to these inferences.
Yaguang Li, Meridith Joyce
doaj   +1 more source

TOPoS

Astronomy & Astrophysics
Context. One technique for determining stellar ages is to compare the position of a star in the Hertzsprung-Russell diagram to theoretical stellar evolutionary tracks.
Bonifacio P., Lebreton Y., Koutsouridou I., Zou Y. P., Romano D., Salvadori S., Sbordone L., Monaco L., Caffau E., Spite M., François P.   +10 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Chemically Self-consistent Modeling of the Globular Cluster NGC 2808 and its Effects on the Inferred Helium Abundance of Multiple Stellar Populations

The Astrophysical Journal
The helium abundances in the multiple populations that are now known to comprise all closely studied Milky Way globular clusters (GCs) are often inferred by fitting isochrones generated from stellar evolutionary models to GC photometry.
Emily M. Boudreaux, Brian C. Chaboyer, Amanda Ash, Renata Edaes Hoh, Gregory Feiden   +4 more
doaj   +1 more source

A Classical Cepheid in a LMC eclipsing binary: evidence of shortcomings in current stellar evolutionary models?

, 2011
The recent discovery and analysis of a classical Cepheid in the well detached, double-lined, eclipsing binary OGLE-LMC-CEP0227, has provided the first determination of the dynamical mass of a classical Cepheid variable to an unprecedented 1% accuracy. We show here that modern stellar evolution models widely employed to study Galactic and extragalactic ...
Cassisi, Santi, Salaris, Maurizio
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source