Results 111 to 120 of about 3,312 (299)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

The effect of stellar feedback and quasar winds on the active galactic nucleus population [PDF]

, 2006
Fabio Fontanot, Pierluigi Monaco, S. Cristiani, P. Tozzi   +3 more
openalex   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Efficacy of early stellar feedback in low gas surface density environments [PDF]

, 2019
Rahul Kannan, Federico Marinacci, Christine M. Simpson, Simon C. O. Glover, Lars Hernquist   +4 more
openalex   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Physical properties and scaling relations of molecular clouds: the effect of stellar feedback [PDF]

, 2018
Kearn Grisdale, Oscar Agertz, Florent Renaud, Alessandro B. Romeo   +3 more
openalex   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

FEASTS Compared with Simulations: Abnormally Irregular and Extended H i Morphologies at a Column Density of 1018 cm−2 in TNG50 and Auriga

The Astrophysical Journal
With new atomic-hydrogen (H i ) observations of FAST Extended Atlas of Selected Targets Survey (FEASTS), we present the first statistical comparison of H i morphology between observations and cosmological simulations, focusing on low-column-density (∼10 ^
Xuchen Lin, Jing Wang, Guinevere Kauffmann, Volker Springel, Rüdiger Pakmor   +4 more
doaj   +1 more source

The SATIN project – I. Turbulent multiphase ISM in Milky Way simulations with SNe feedback from stellar clusters [PDF]

, 2023
Rebekka Bieri, Thorsten Naab, Sam Geen, Jonathan Coles, Rüdiger Pakmor, Stefanie Walch   +5 more
openalex   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source