Results 91 to 100 of about 3,312 (299)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Stellar Feedback & Bulge Formation in Clumpy Disks

, 2011
11 pages, 4 figures, MNRAS (Revised to match accepted version, additional numerical tests added).
Hopkins, Philip F., Keres, Dusan, Murray, Norman, Quataert, Eliot, Hernquist, Lars   +4 more
openaire   +2 more sources

Metallicity Gradients in Modern Cosmological Simulations. I. Tension between Smooth Stellar Feedback Models and Observations

The Astrophysical Journal
The metallicity of galaxies, and its variation with galactocentric radius, provides key insights into the formation histories of galaxies and the physical processes driving their evolution.
Alex M. Garcia, Paul Torrey, Aniket Bhagwat, Ruby J. Wright, Qian-Hui Chen, Kathryn Grasha, Sophia Ridolfo, Z. S. Hemler, Arnab Sarkar, Priyanka Chakraborty, Erica J. Nelson, Ryan L. Sanders, Tiago Costa, Mark Vogelsberger, Lisa J. Kewley, Sara L. Ellison, Lars Hernquist   +16 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Impact of Positive AGN Feedback on the Properties of Galaxies in a Semianalytic Model of Galaxy Formation

The Astrophysical Journal Supplement Series
We introduce the state-of-the-art semianalytic model Formation and Evolution of GAlaxies (FEGA), which incorporates updated prescriptions for key physical processes in galaxy formation.
Emanuele Contini, Sukyoung K. Yi, Seyoung Jeon, Jinsu Rhee   +3 more
doaj   +1 more source

Stellar feedback and triggered star formation in the prototypical bubble RCW 120. [PDF]

Sci Adv, 2021
Luisi M, Anderson LD, Schneider N, Simon R, Kabanovic S, Güsten R, Zavagno A, Broos PS, Buchbender C, Guevara C, Jacobs K, Justen M, Klein B, Linville D, Röllig M, Russeil D, Stutzki J, Tiwari M, Townsley LK, Tielens AGGM.   +19 more
europepmc   +1 more source

Stellar feedback in M83 as observed with MUSE [PDF]

, 2022
Lorenza Della Bruna, Angela Adamo, P. Amram, Erik Rosolowsky, Christopher Usher, Mattia Sirressi, Andreas Schruba, Éric Emsellem, Adam K. Leroy, Arjan Bik, William P. Blair, Anna F. McLeod, Göran Östlin, Florent Renaud, Carmelle Robert, Laurie Rousseau-Nepton, L. J. Smith   +16 more
openalex   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source