Results 71 to 80 of about 3,312 (299)
The Astrophysical Journal LettersWe investigate how pulsar timing array (PTA) measurements of the nanohertz gravitational-wave background (GWB) can constrain models for the growth history of supermassive black holes (SMBHs) and how active galactic nucleus (AGN) and stellar feedback ...
Megan Taylor Tillman +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
The Astrophysical JournalWe investigate how differences in the stellar feedback produce disks with different morphologies in Milky Way–like progenitors over 1 ≤ z ≤ 5, using eight state-of-the-art cosmological hydrodynamics simulation codes in the AGORA project.
Minyong Jung +27 more
doaj +1 more source
The star formation factory revisited
Astronomy & AstrophysicsContext. Stellar feedback regulates star formation and shapes the interstellar medium, yet its role during the collapse of molecular clouds remains uncertain over a wide range of initial conditions. Aims.
Jiménez S. +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Protostellar Jets in Star Cluster Formation and Evolution. I. Implementation and Initial Results
The Astronomical JournalStars form in clusters from the gravitational collapse of giant molecular clouds, which is opposed by a variety of physical processes, including stellar feedback. The interplay between these processes determines the star formation rate of the clouds.
Sabrina M. Appel +10 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Massive Interacting Binaries Enhance Feedback in Star-forming Regions
The Astrophysical JournalWe present a new framework to incorporate feedback from massive interacting binaries in simulations of star cluster formation. Our new feedback model adds binary stellar evolution to the cluster formation code Torch , and couples it in Amuse to the ...
Claude Cournoyer-Cloutier +11 more
doaj +1 more source
Star Formation Variability as a Probe for the Baryon Cycle within Galaxies
The Astrophysical Journal, 2023 We investigate the connection between the regulation of star formation and the cycling of baryons both within and in and out of galaxies. We use idealized numerical simulations of Milky Way–mass galaxies, in which we vary the galaxy morphology and ...
Eun-jin Shin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source