Results 71 to 80 of about 1,238,105 (253)

Simulating supernova feedback in galaxy disks [PDF]

, 2012
In this thesis I examine supernova feedback in hydrodynamical simulations of galaxy disks. Understanding this process entails the numerical evaluation of cooling in radiative shocks, and we present a set of simulations using two widely used numerical ...
CREASEY, PETER,EDWARD, Creasey, Peter Edward   +1 more
core  

STAR FORMATION IN DISK GALAXIES. III. DOES STELLAR FEEDBACK RESULT IN CLOUD DEATH? [PDF]

, 2015
Stellar feedback, star formation, and gravitational interactions are major controlling forces in the evolution of giant molecular clouds (GMCs). To explore their relative roles, we examine the properties and evolution of GMCs forming in an isolated ...
Wadsley, James, Tasker, Elizabeth J., Pudritz, Ralph   +2 more
core   +1 more source

A Cooler Look at the Environment of Cygnus X-1: Searching for Dynamical Interactions within Cold Molecular Gas

The Astrophysical Journal
We present IRAM 30 m observations aimed at identifying potential outflow–interstellar medium interaction sites in the vicinity of the black hole X-ray binary Cygnus X-1, which displays persistent relativistic jets and a prominent stellar wind. Using this
Pau Bosch-Cabot, Alexandra J. Tetarenko, Valentí Bosch-Ramon, James C. A. Miller-Jones, David Russell, Sara E. Motta, Pikky Atri, María Díaz-Trigo, Isabella Mariani, Steve Prabu   +9 more
doaj   +1 more source

Validating the CROCODILE Model Within the AGORA Galaxy Simulation Framework

Galaxies
Numerical galaxy formation simulations are sensitive to numerical methods and sub-grid physics models, making code comparison projects essential for quantifying uncertainties.
Pablo Granizo, Yuri Oku, Kentaro Nagamine   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Stellar feedback and bulge formation in clumpy discs

, 2019
We use numerical simulations of isolated galaxies to study the effects of stellar feedback on the formation and evolution of giant star-forming gas 'clumps' in high-redshift, gas-rich galaxies.
Murray, Norman, Hopkins, Philip F., Hernquist, Lars, Quataert, Eliot, Kereš, Dusan   +4 more
core   +1 more source

Shooting for the Stars: Jet-mode Feedback and AGN Jet Deceleration from Stellar Mass Loading

The Astrophysical Journal
Active Galactic Nucleus (AGN) jets are thought to be vital ingredients in galaxy evolution through the action of kinetic feedback; however, how narrow, relativistic outflows couple to galaxies remains an open question.
Talia M. O’Shea, Sebastian Heinz, Melinda Soares-Furtado, Zsofi Igo, Andrea Merloni   +4 more
doaj   +1 more source

Theoretical Re-evaluations of Scaling Relations between SMBHs and Their Host Galaxies–2. Importance of AGN Feedback Suggested by Stellar Age–Velocity Dispersion Relation

Frontiers in Astronomy and Space Sciences, 2017
We present the galactic stellar age—velocity dispersion relation obtained from a semi-analytic model of galaxy formation. We divide galaxies into two populations: galaxies which have over-massive/under-massive black holes (BHs) against the best-fitting ...
Hikari Shirakata, Toshihiro Kawaguchi, Takashi Okamoto, Tomoaki Ishiyama   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source