Results 81 to 90 of about 3,312 (299)

X-ray stellar feedback in low-metallicity starbursts

Astronomy & Astrophysics
Context. The X-ray output of low-metallicity starburst galaxies is a key component of stellar feedback, tracing the processes responsible for gas ionization and chemical enrichment.
Chatzis M., Oskinova L. M., Reyero Serantes S., Lehmer B. D., Östlin G., Bik A., Hayes M., Mas-Hesse J. M., Gallagher J. S., Fürst F.   +9 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Role of Stellar Feedback in Galaxy Evolution

, 2009
Aiming at understanding the role of stellar feedback in galaxy evolution, I present a study of the hot interstellar medium in several representative galaxies, based primarily on X-ray observations as well as theoretical modelling. I find that, in the massive disk galaxies NGC2613 and M104, the observed amount of hot gas is much less than that ...
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Searching for Stellar-feedback-driven Outflow Signatures: A Deep Dive into NGC 3741

The Astrophysical Journal
Stellar feedback drives winds and outflows critical to the baryon cycles of low-mass galaxies whose shallow gravitational potential wells make them particularly susceptible to mass and metal loss through outflows. However, spatially resolved observations
Lexi N. Gault, Liese van Zee, Elizabeth A. K. Adams, James M. Wells, Laura Congreve Hunter, Kristen B. W. McQuinn, Roger E. Cohen, O. Grace Telford   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Bursty Star Formation in Dwarfs is Sensitive to Numerical Choices in Supernova Feedback Models

The Astrophysical Journal
Simulations of galaxy formation are mostly unable to resolve the energy-conserving phase of individual supernova events, having to resort to subgrid models to distribute the energy and momentum resulting from stellar feedback.
Eric Zhang, Laura V. Sales, Federico Marinacci, Paul Torrey, Mark Vogelsberger, Volker Springel, Hui Li, Rüdiger Pakmor, Thales A. Gutcke   +8 more
doaj   +1 more source

Validating the CROCODILE Model Within the AGORA Galaxy Simulation Framework

Galaxies
Numerical galaxy formation simulations are sensitive to numerical methods and sub-grid physics models, making code comparison projects essential for quantifying uncertainties.
Pablo Granizo, Yuri Oku, Kentaro Nagamine   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source