Results 81 to 90 of about 1,238,105 (253)

Probing the dawn of galaxies: star formation and feedback in the JWST era through the GAEA model

Astronomy & Astrophysics
The James Webb Space Telecope opened a new window for the study of the highest redshift (z > 7) Universe. This work presents a theoretical investigation of the very high-redshift Universe using the state-of-the-art GALaxy Evolution and Assembly (GAEA ...
Cantarella Sebastiano, De Lucia Gabriella, Fontanot Fabio, Hirschmann Michaela, Xie Lizhi, Franco Maximilien, Plat Adèle   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Disentangling planetary orbits from stellar activity in radial-velocity surveys [PDF]

, 2013
The majority of extra-solar planets have been discovered (or confirmed after follow-up) through radial-velocity (RV) surveys. Using ground-based spectrographs such as High Accuracy Radial Velocity Planetary Search (HARPS) and HARPS-North, it is now ...
Segransan, Damien, Pollacco, Don, Fares, R, Pollacco, D, Queloz, D., Haywood, R.D., Pollacco, D., Gillon, M, Gillon, M., Barros, SCC, Lanza, AF, Pepe, F., Cameron, A. Collier, Hatzes, A., Ségransan, D., Lovis, C, Lovis, Christophe, Moutou, C, Barros, S. C. C., Santerne, A., Unruh, Y., Haywood, R. D., Unruh, Y, Fares, R., Segransan, D, Moutou, C., Deleuil, M., Barros, S.C.C., Cameron, AC, Lanza, A.F., Pepe, F, Deleuil, M, Haywood, RD, Gillon, Michaël, Pepe, Francesco Alfonso, Santerne, A, Queloz, Didier, Lovis, C., Cameron, A.C., Hatzes, A, Lanza, A. F., Queloz, D, Cameron, A.C.; id_orcid   +42 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

The IMF of stellar clusters: effects of accretion and feedback

, 2010
We have developed a model which describes the co-evolution of the mass function of dense gravitationally bound cores and of the stellar mass function in a protocluster clump.
Dib, Sami, Padoan, Paolo, Maheswar, G., Ojha, D. K., Khajenabi, Fazeleh, Shadmehri, Mohsen   +5 more
core   +1 more source

Searching for Stellar-feedback-driven Outflow Signatures: A Deep Dive into NGC 3741

The Astrophysical Journal
Stellar feedback drives winds and outflows critical to the baryon cycles of low-mass galaxies whose shallow gravitational potential wells make them particularly susceptible to mass and metal loss through outflows. However, spatially resolved observations
Lexi N. Gault, Liese van Zee, Elizabeth A. K. Adams, James M. Wells, Laura Congreve Hunter, Kristen B. W. McQuinn, Roger E. Cohen, O. Grace Telford   +7 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Effects of stellar feedback on cores in STARFORGE

Stars form in dense cores within molecular clouds, and newly formed stars influence their natal environments. How stellar feedback impacts core properties and evolution has been the subject of extensive investigation.
S. Neupane, K. M. Menten, A. Karska, M. Y. Grudić, Grudić, M., Karska, A., F. Wyrowski, Colombo, D., D. Colombo, Neupane, S., Wyrowski, F., K. R. Neralwar, S. Offner, Menten, K., Neralwar, K., Offner, S., Menten, K. M., Grudić, M Y., Neralwar, K. R.   +18 more
core   +1 more source

Black holes on FIRE: stellar feedback limits early feeding of galactic nuclei [PDF]

, 2017
We introduce massive black holes (BHs) in the Feedback In Realistic Environments (FIRE) project and perform high-resolution cosmological hydrodynamic simulations of quasar-mass haloes [Mhalo(z = 2) ≈ 1012.5 M⊙] down to z = 1.
Daniel Anglés-Alcázar, Hopkins, Philip F, Torrey, Paul, Feldmann, Robert, Paul Torrey, Hopkins, Philip F; https://orcid.org/, Dušan Kereš, Quataert, Eliot, Kereš, Dušan, Robert Feldmann, Eliot Quataert, Anglés-Alcázar, Daniel, Claude-André Faucher-Giguère, Philip F. Hopkins, Wetzel, Andrew, Faucher-Giguère, Claude-André, Andrew Wetzel, Hopkins, Philip F.   +17 more
core   +1 more source