Results 151 to 160 of about 2,418 (298)

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Molecular Hydrogen Controls the Temperatures of Flares on TRAPPIST-1

The Astrophysical Journal Letters
Early JWST observations of TRAPPIST-1 have revealed an unexpected puzzle: energetic white-light flares ( E  > 10 ^30 erg) reach temperatures of only ∼3500–4000 K, nearly 3 times cooler than typical solar flares, which peak around 9000–10,000 K.
A. I. Shapiro, N. Kostogryz, S. Seager, V. Witzke, J. de Wit, V. Vasilyev, Astrid M. Veronig, Cameron Robert, Peter Hardi, S. K. Solanki   +9 more
doaj   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

‘Where are the adults?’: Troubling child‐activism and children's political participation

British Educational Research Journal, EarlyView.
Abstract Children's political participation is a well‐established theme in childhood studies. In this article we offer an original account of child activism that takes into account the entangled and emergent aspect of children as activists. We begin with a historical and a conceptual review, noting the importance of mid‐20th century developments such ...
Sharon Hunter, Claire Cassidy
wiley   +1 more source

A semi-analytical model of stellar flares [PDF]

, 1990
We present a simplified point'' model to describe the hydrodynamic response of coronal loop plasma to the sudden release of energy which occurs at the time of a flare.
Kopp, R.A. (Los Alamos National Lab., NM (USA)), Poletto, G. (Osservatorio Astrofisico di Arcetri, Florence (Italy))   +1 more
core  

Making teaching an attractive profession: What are the challenges and opportunities for minority ethnic teachers in England?

British Educational Research Journal, EarlyView.
Abstract This paper explores the challenges and opportunities surrounding the recruitment and retention of minority ethnic teachers in England. Drawing on interview data from 33 teachers and school leaders of diverse ethnic backgrounds, it investigates whether racialised barriers identified in earlier research have shifted in the current context of ...
Antonina Tereshchenko, Feyisa Demie, Stephen Gorard, Yiyang Gao, Beng Huat See, Nadia Siddiqui   +5 more
wiley   +1 more source

Probing Starspot Dynamics on the Active M Dwarf TIC 272272592: A Multiyear TESS Study

The Astrophysical Journal
We present an analysis of temporal starspot evolution and its distribution on an active rapid rotator ( P _rot = 1.22 days), TIC 272272592, using high-precision time-series photometry from the Transiting Exoplanet Survey Satellite spanning over 3 yr. The
Rajib Kumbhakar, Soumen Mondal, Samrat Ghosh, Diya Ram, Dorothy M. Mwanzia   +4 more
doaj   +1 more source

Quasi-periodic pulsations in solar and stellar flares [PDF]

Quasi-periodic pulsations (QPPs) are a phenomenon commonly observed in solar flares, and are also occasionally observed in stellar flares. They are time variations in the intensity of the flare emission that repeat with approximately constant timescales,
Pugh, Chloe E.
core  

Does Sustainability Auditing Lead to Enhanced Corporate Governance, Environmental Performance, and Financial Outcomes? Empirical Evidence From High‐Impact Industries

Business Strategy and the Environment, EarlyView.
ABSTRACT This study employs hierarchical regression modelling on a survey of 550 firms from Nigeria and Ghana to examine the impact of sustainability auditing on corporate governance, environmental performance, and financial outcomes of high‐impact industries.
Mandella Osei‐Assibey Bonsu, Ying Wang, Grace Eghe‐Ikhurhe, Katie Hyslop   +3 more
wiley   +1 more source

Effect of Time-varying X-Ray Emission from Stellar Flares on the Ionization of Protoplanetary Disks

The Astrophysical Journal
X-rays have significant impacts on cold, weakly ionized protoplanetary disks by increasing the ionization rate and driving chemical reactions. Stellar flares are explosions that emit intense X-rays and are the unique source of hard X-rays with an energy ...
Haruka Washinoue, Shinsuke Takasao, Kenji Furuya   +2 more
doaj   +1 more source