Results 141 to 150 of about 171,183 (290)

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Starspot Distribution and Flare Events in Two Young Low-mass Stars Using TESS Data

The Astrophysical Journal
Wide-field high-precision photometric observations such as the Transiting Exoplanet Survey Satellite (TESS) allowed the investigation of the stellar magnetic activity of cool stars. M dwarf starspots and stellar flares are the main indicators of magnetic
Rajib Kumbhakar, Soumen Mondal, Samrat Ghosh, Diya Ram   +3 more
doaj   +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

Interpreting nebular emission lines in the high-redshift Universe

The Open Journal of Astrophysics
One of the most remarkable outcomes from \textit{JWST} has been the exquisite UV-optical spectroscopic data for galaxies in the high-redshift Universe ($z \geq 5$), enabling the use of various nebular emission lines to infer conditions of the ...
Aswin Payyoor Vijayan, Robert M. Yates, Christopher C Lovell, William J Roper, Stephen M Wilkins, Hiddo S B Algera, Shihong Liao, Paurush Punyasheel, Lucie E Rowland, Louise T C Seeyave   +9 more
doaj   +1 more source

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

The Solar-like Latitudinal Distribution of Flaring Activities Revealed by TESS, APOGEE, and GALAH

The Astrophysical Journal Supplement Series
Flare flux reflects the contribution from active regions rather than the contribution from the entire hemisphere of a star. Unlike the amplitude of light curves caused by starspots, flare detection is independent of inclination.
Huiqin Yang, Shuai Liu, Yang Huang, Bowen Zhang, Jifeng Liu   +4 more
doaj   +1 more source

Stellar flare detection in XMM-Newton with gradient-boosted trees

Astronomy & Astrophysics
Context. The EXTraS project, based on data collected with the XMM-Newton observatory, provides us with a vast amount of light curves for X-ray sources. For each light curve, EXTraS also provides us with a set of features.
Pasquato Mario, Marelli Martino, De Luca Andrea, Salvaterra Ruben, Carenini Gaia, Belfiore Andrea, Tiengo Andrea, Esposito Paolo   +7 more
doaj   +1 more source

Persistent IL‐18 fuels expansion of CD38+HLA‐DR+CD8+ T cells in Still's disease and macrophage activation syndrome

Arthritis &Rheumatology, Accepted Article.
Objective Still's disease (SD) is an autoinflammatory disorder characterized by remarkably high IL‐18 levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further IL‐18 ...
Greta Rogani, Remco G.A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T.M. Putmans, Freya M.C.H. Huijsmans, Lyanne J.P.M. Sijbers, Aafke M. De Ligt, Maurice J.H. Van Haaren, Rianne C. Scholman, Noël M.M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastian J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

Arthritis &Rheumatology, Accepted Article.
Objectives VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani, Tatsuma Ban, Yohei Kirino, Go R Sato, Soichiro Adachi, Yuki Iizuka, Kayo Harita, Ayaka Maeda, Osamu Ohara, Hideaki Nakajima, Tomohiko Tamura   +10 more
wiley   +1 more source

Combined Anterior Cruciate Ligament Reconstruction and Lateral Extra‐articular Tenodesis With Augmented Continuous Iliotibial Band Autograft

Arthroscopy Techniques, EarlyView.
Abstract The purpose of this technical note is to describe a reproducible surgical technique for anterior cruciate ligament reconstruction combined with a lateral tenodesis using a continuous iliotibial band autograft that allows self‐augmentation of graft diameter without the need for additional tendon harvesting.
Gregoire Zerr, David Eichler, Pierre Imbert, Christian Lutz   +3 more
wiley   +1 more source