Results 101 to 110 of about 3,795,687 (315)

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Modeling the Mass Distribution and Gravitational Potential of Nearby Disk Galaxies: Implications for the Interstellar Medium Dynamical Equilibrium

The Astrophysical Journal
We characterize stellar, gas, and dark matter mass distributions for 17 nearby massive disk galaxies from the PHANGS sample. This allows us to compute the gravitational potential that vertically confines the interstellar gas and determines its ...
Vivek Vijayakumar, Jiayi Sun, Eve C. Ostriker, Enrico M. Di Teodoro, Konstantin Haubner, Chang-Goo Kim, Adam K. Leroy, Miguel Querejeta   +7 more
doaj   +1 more source

Galaxy and Mass Assembly (GAMA): The stellar mass budget of galaxy spheroids and discs [PDF]

, 2016
We build on a recent photometric decomposition analysis of 7506 Galaxy and Mass Assembly (GAMA) survey galaxies to derive stellar mass function fits to individual spheroid and disk component populations down to a lower mass limit of log(M_*/M_sun)= 8. We
A. Moffett, R. Lange, S. Driver, A. Robotham, L. Kelvin, M. Alpaslan, S. Andrews, J. Bland-Hawthorn, S. Brough, M. Cluver, M. Colless, L. Davies, B. Holwerda, A. Hopkins, P. Kafle, J. Liske, M. Meyer   +16 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

An Early Dark Matter–dominated Phase in the Assembly History of Milky Way–mass Galaxies Suggested by the TNG50 Simulation and JWST Observations

The Astrophysical Journal Letters
Whereas well-studied galaxies at cosmic noon are found to be baryon dominated within the effective radius, recent JWST observations of z ∼ 6–7 galaxies with stellar masses of only M _* ∼ 10 ^8−9 M _⊙ surprisingly indicate that they are dark matter ...
Anna de Graaff, Annalisa Pillepich, Hans-Walter Rix   +2 more
doaj   +1 more source

A supra-massive population of stellar-mass black holes in the globular cluster Palomar 5. [PDF]

Nat Astron, 2021
Gieles M, Erkal D, Antonini F, Balbinot E, Peñarrubia J.   +4 more
europepmc   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source