Results 101 to 110 of about 3,828,801 (363)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

RELATIONS BETWEEN CENTRAL BLACK HOLE MASS AND TOTAL GALAXY STELLAR MASS IN THE LOCAL UNIVERSE [PDF]

open access: yes, 2015
Scaling relations between central black hole (BH) mass and host galaxy properties are of fundamental importance to studies of BH and galaxy evolution throughout cosmic time.
A. Reines, M. Volonteri
semanticscholar   +1 more source

The Growth of Galaxy Stellar Haloes over 0.2 ≤ z ≤ 1.1

open access: yesThe Astrophysical Journal
Galaxies are predicted to assemble their stellar haloes through the accretion of stellar material from interactions with their cosmic environment. Observations that trace stellar halo buildup probe the processes that drive galaxy size and stellar mass ...
Devin J. Williams   +11 more
doaj   +1 more source

Revealing the Galaxy–Halo Connection through Machine Learning

open access: yesThe Astrophysical Journal, 2023
Understanding the connections between galaxy stellar mass, star formation rate, and dark matter halo mass represents a key goal of the theory of galaxy formation. Cosmological simulations that include hydrodynamics, physical treatments of star formation,
Ryan Hausen   +7 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

The total stellar halo mass of the Milky Way [PDF]

open access: yesMonthly notices of the Royal Astronomical Society, 2019
We measure the total stellar halo luminosity using red giant branch (RGB) stars selected from Gaia data release 2. Using slices in magnitude, colour, and location on the sky, we decompose RGB stars belonging to the disc and halo by fitting two ...
A. Deason, V. Belokurov, J. Sanders
semanticscholar   +1 more source

The Correlations of Stellar Tidal Disruption Rates with Properties of Massive Black Holes and Their Host Galaxies

open access: yesThe Astrophysical Journal, 2023
Stars can be either disrupted as tidal disruption events (TDEs) or swallowed whole by massive black holes (MBHs) at galactic centers when they approach sufficiently close to these MBHs.
Yunfeng Chen, Qingjuan Yu, Youjun Lu
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Galaxy And Mass Assembly (GAMA): stellar mass growth of spiral galaxies in the cosmic web [PDF]

open access: yes, 2016
We look for correlated changes in stellar mass and star formation rate (SFR) along filaments in the cosmic web by examining the stellar masses and UV-derived SFRs of 1799 ungrouped and unpaired spiral galaxies that reside in filaments. We devise multiple
M. Alpaslan   +18 more
semanticscholar   +1 more source

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