Results 131 to 140 of about 3,795,687 (315)

New planetary system with Neptune-mass planet and massive sub-stellar object discovered by astronomers

, 2022
Eddy Telmort
openalex   +2 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Environmental Evidence for Overly Massive Black Holes in Low-mass Galaxies and a Black Hole–Halo Mass Relation at z ∼ 5

The Astrophysical Journal
JWST observations have unveiled faint active galactic nuclei (AGNs) at high redshift that provide insights into the formation of supermassive black holes (SMBHs). However, disentangling their stellar from AGN light is challenging.
Jorryt Matthee, Rohan P. Naidu, Gauri Kotiwale, Lukas J. Furtak, Ivan Kramarenko, Ruari Mackenzie, Jenny Greene, Angela Adamo, Rychard J. Bouwens, Claudia Di Cesare, Anna-Christina Eilers, Anna de Graaff, Kasper E. Heintz, Daichi Kashino, Michael V. Maseda, Sandro Tacchella, Alberto Torralba   +16 more
doaj   +1 more source

The zCOSMOS redshift survey: the role of environment and stellar mass in shaping the rise of the morphology-density relation from z ~ 1 [PDF]

, 2009
L. Tasca, Jean‐Paul Kneib, A. Iovino, O. Le Fèvre, K. Kovač, M. Bolzonella, S. J. Lilly, Roberto Abraham, P. Cassata, O. Cucciati, L. Guzzo, L. Tresse, G. Zamorani, P. Capak, B. Garilli, M. Scodeggio, Kartik Sheth, E. Zucca, C. M. Carollo, T. Contini, V. Mainieri, A. Renzini, S. Bardelli, A. Bongiorno, K. I. Caputi, G. Coppa, S. de la Torre, L. de Ravel, P. Franzetti, P. Kampczyk, C. Knobel, Anton M. Koekemoer, F. Lamareille, J. -F. Le Borgne, V. Le Brun, C. Maier, M. Mignoli, R. Pelló, Y. Peng, E. Pérez‐Montero, E. Ricciardelli, J. D. Silverman, D. Vergani, M. Tanaka, U. Abbas, D. Bottini, A. Cappi, A. Cimatti, O. Ilbert, A. Leauthaud, D. Maccagni, C. Marinoni, H. J. McCracken, P. Memeo, B. Meneux, Pascal A. Oesch, C. Porciani, L. Pozzetti, R. Scaramella, Claudia Scarlata   +59 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Velocity Dispersions of Quiescent Galaxies in IllustrisTNG

The Astrophysical Journal
We examine the central stellar velocity dispersion of subhalos based on IllustrisTNG cosmological hydrodynamic simulations. The central velocity dispersion is a fundamental observable that links galaxies with their dark matter subhalos.
Jubee Sohn, Margaret J. Geller, Josh Borrow, Mark Vogelsberger   +3 more
doaj   +1 more source

LOW MASS STELLAR EVOLUTION WITH WIMP CAPTURE AND ANNIHILATION [PDF]

, 2008
Pat Scott, Joakim Edsjö, Malcolm Fairbairn   +2 more
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Large Dark Matter Content and Steep Metallicity Profile Predicted for Ultradiffuse Galaxies Formed in High-spin Halos

The Astrophysical Journal
We study the stellar properties of a sample of simulated ultradiffuse galaxies (UDGs) with stellar mass M _⋆ = 10 ^7.5 –10 ^9 M _⊙ , selected from the TNG50 simulation, where UDGs form mainly in high-spin dwarf-mass halos.
José A. Benavides, Laura V. Sales, Mario. G. Abadi, Mark Vogelsberger, Federico Marinacci, Lars Hernquist   +5 more
doaj   +1 more source