Results 151 to 160 of about 111,751 (340)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Deep Galaxy Stellar Mass Functions As a Function of Star Formation Rate in the Virgo Cluster Environment

The Astrophysical Journal
We analyze deep ( M _* ≳ 10 ^7 M _⊙ ) galaxy stellar mass functions (SMFs) of the Virgo cluster using stellar masses derived as part of the Next Generation Virgo Survey. The total SMF has a slope of $\alpha =-1.3{5}_{-0.02}^{+0.02}$ , which is similar to
Cameron R. Morgan, Elizaveta Sazonova, Ian D. Roberts, Michael L. Balogh, Joel Roediger, Laura Ferrarese, Patrick Côté, Alessandro Boselli, Matteo Fossati, Jean-Charles Cuillandre, Stephen Gwyn   +10 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Velocity dispersion functions of pressure-supported galaxies in EAGLE simulations with varying active galactic nucleus feedback

Astronomy & Astrophysics
We investigated the stellar velocity dispersion functions (VDFs) of pressure-supported galaxies in the EAGLE cosmological simulations. The central stellar velocity dispersion is one of the fundamental dynamical tracers of the total mass of galaxy ...
Choi Jungwon, Sohn Jubee
doaj   +1 more source

Testing galaxy formation models with galaxy stellar mass functions [PDF]

, 2016
Seunghwan Lim, H. J. Mo, T.-W. Lan, Brice Ménard   +3 more
openalex   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

ELVES-Dwarf. I. Satellite Systems of Eight Isolated Dwarf Galaxies in the Local Volume

The Astrophysical Journal
The satellite populations of Milky Way (MW)–mass systems have been extensively studied, significantly advancing our understanding of galaxy formation and dark matter physics.
Jiaxuan Li, Jenny E. Greene, Shany Danieli, Scott G. Carlsten, Marla Geha, Fangzhou Jiang, Masayuki Tanaka   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

LATIS: Constraints on the Galaxy–Halo Connection at z ∼ 2.5 from Galaxy–Galaxy and Galaxy–Lyα Clustering

The Astrophysical Journal
The connection between galaxies and dark matter halos is often quantified using the stellar mass–halo mass (SMHM) relation. Optical and near-infrared imaging surveys have led to a broadly consistent picture of the evolving SMHM relation based on ...
Andrew B. Newman, Mahdi Qezlou, Nima Chartab, Gwen C. Rudie, Guillermo A. Blanc, Simeon Bird, Andrew J. Benson, Daniel D. Kelson, Brian C. Lemaux   +8 more
doaj   +1 more source

The stellar initial mass function in the early universe revealed from old stellar populations in our neighbourhood [PDF]

, 2012
Yutaka Komiya, Shimako Yamada, Takuma Suda, Masayuki Y. Fujimoto   +3 more
openalex   +1 more source