Results 141 to 150 of about 111,751 (340)

The GALEX Arecibo SDSS Survey VII: The Bivariate Neutral Hydrogen-Stellar Mass Function for Massive Galaxies

open access: yes, 2013
We present the bivariate neutral atomic hydrogen (HI)---stellar mass function (HISMF) (phi(M_HI, M_*)) for massive (log M_*/M_sun > 10) galaxies derived from a sample of 480 local (0.025 < z < 0.050) galaxies observed in HI at Arecibo as part of the ...
Catinella, Barbara   +4 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Distribution Function-based Modeling of Discrete Kinematic Datasets, in Application to the Milky Way Nuclear Star Cluster

open access: yesThe Astrophysical Journal
We present a method for constructing dynamical models of stellar systems described by distribution functions and constrained by discrete-kinematic data.
Eugene Vasiliev   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

The Assembly of Supermassive Black Holes at z < 1 in Early-type Galaxies from Scaling Relations

open access: yesThe Astrophysical Journal
The assembly of supermassive black hole (SMBH) mass ( M _• ) and stellar mass ( M _* ) in galaxies can be studied via the redshift evolution of the M _• – M _* relation, but the ways in which selection bias and physical assembly channels affect this ...
D. Farrah   +16 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

The Stellar Initial Mass Function in The Galactic Center [PDF]

open access: yes, 2007
Massive stars define the upper limits of the star formation process, dominate the energetics of their local environs, and significantly affect the chemical evolution of galaxies. Their role in starburst galaxies and the early Universe is likely to be important, but we still do not know the maximum mass that a star can possess, i.e.``the upper mass ...
openaire   +2 more sources

Empirical Color Correction to MIST and PARSEC Isochrones on Gaia BR − RP and G − RP with Benchmark Open Clusters

open access: yesThe Astrophysical Journal
Recent literature reports a color deviation between observed Gaia color–magnitude diagrams (CMDs) and theoretical model isochrone predictions, particularly in the very low-mass regime.
Fan Wang   +10 more
doaj   +1 more source

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