Results 131 to 140 of about 111,751 (340)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Abundance Pattern Fitting with Bayesian Inference: Constraining First Stars’ Properties and Their Explosion Mechanism with Extremely Metal-poor Stars

The Astrophysical Journal
The abundance patterns of extremely metal-poor stars preserve a fossil record of the Universe’s earliest chemical enrichment by the supernova explosions from the evolution of first generation of stars, also referred to as Population III stars.
Ruizheng Jiang, Haining Li, Gang Zhao, Qianfan Xing, Wenyu Xin   +4 more
doaj   +1 more source

Ages, Distances, and the Initial Mass Functions of Stellar Clusters [PDF]

, 2000
J. R. Stauffer, R. D. Jeffries, E. L. Martı́n, D. M. Terndrup   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Stellar Mass Function From SIM Astrometry/Photometry

, 1999
Talk given at "Working on the Fringe", Dana Point, CA, May 24 1999, 5 ...
Gould, Andrew, Salim, Samir
openaire   +2 more sources

On the Determination of Stellar Mass and Binary Fraction of Open Clusters within 500 pc from the Sun

The Astrophysical Journal
We investigated the stellar mass function and the binary fraction of 114 nearby open clusters (OCs) using the high-precision photometric data from Gaia Data Release 3 (Gaia DR3).
Yueyue Jiang, Jing Zhong, Songmei Qin, Tong Tang, Li Chen, Jinliang Hou   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Big Galaxies and Big Black Holes: The Massive Ends of the Local Stellar and Black Hole Mass Functions and the Implications for Nanohertz Gravitational Waves

The Astrophysical Journal Letters
We construct the z = 0 galaxy stellar mass function (GSMF) by combining the GSMF at stellar masses M _* ≲ 10 ^11.3 M _⊙ from the census study of Leja et al.
Emily R. Liepold, Chung-Pei Ma
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dust driven mass loss from carbon stars as function of stellar parameters - II. Effects of grain size on wind properties [PDF]

, 2011
Lars Mattsson, S. Höfner
openalex   +1 more source