Results 111 to 120 of about 2,874 (264)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The Astrophysical JournalWe analyze deep ( M _* ≳ 10 ^7 M _⊙ ) galaxy stellar mass functions (SMFs) of the Virgo cluster using stellar masses derived as part of the Next Generation Virgo Survey. The total SMF has a slope of $\alpha =-1.3{5}_{-0.02}^{+0.02}$ , which is similar to
Cameron R. Morgan +10 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
ELVES-Dwarf. I. Satellite Systems of Eight Isolated Dwarf Galaxies in the Local Volume
The Astrophysical JournalThe satellite populations of Milky Way (MW)–mass systems have been extensively studied, significantly advancing our understanding of galaxy formation and dark matter physics.
Jiaxuan Li +6 more
doaj +1 more source
Astronomy & AstrophysicsWe investigated the stellar velocity dispersion functions (VDFs) of pressure-supported galaxies in the EAGLE cosmological simulations. The central stellar velocity dispersion is one of the fundamental dynamical tracers of the total mass of galaxy ...
Choi Jungwon, Sohn Jubee
doaj +1 more source
The Local Stellar Initial Mass Function
, 2000 This contribution describes the difficult task of inferring the IMF from local star-count data, by discussing the mass-luminosity relation, unresolved binary, triple and quadruple systems, abundance and age spreads and Galactic structure, all of which must be accounted for properly for the results to be meaningful.
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Astrophysical JournalThe connection between galaxies and dark matter halos is often quantified using the stellar mass–halo mass (SMHM) relation. Optical and near-infrared imaging surveys have led to a broadly consistent picture of the evolving SMHM relation based on ...
Andrew B. Newman +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source