Results 101 to 110 of about 2,874 (264)

The Origin of The Stellar Initial Mass Function

, 2000
Observations and theories of the stellar initial mass function are reviewed. The universality and large total mass range of the power law portion of the IMF suggest a connection between stellar mass and cloud structure. The fractal patterns and formation times of young clusters suggest a further connection to turbulence.
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Distribution Function-based Modeling of Discrete Kinematic Datasets, in Application to the Milky Way Nuclear Star Cluster

The Astrophysical Journal
We present a method for constructing dynamical models of stellar systems described by distribution functions and constrained by discrete-kinematic data.
Eugene Vasiliev, Anja Feldmeier-Krause, Mattia C. Sormani   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Assembly of Supermassive Black Holes at z < 1 in Early-type Galaxies from Scaling Relations

The Astrophysical Journal
The assembly of supermassive black hole (SMBH) mass ( M _• ) and stellar mass ( M _* ) in galaxies can be studied via the redshift evolution of the M _• – M _* relation, but the ways in which selection bias and physical assembly channels affect this ...
D. Farrah, A. Engholm, E. Hatziminaoglou, S. Petty, F. Shankar, A. Efstathiou, K. Ejercito, K. Jones, M. Lacy, C. Lonsdale, C. Pearson, G. Tarlé, R. A. Windhorst, J. Afonso, D. L. Clements, K. S. Croker, L. K. Pitchford   +16 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Empirical Color Correction to MIST and PARSEC Isochrones on Gaia BR − RP and G − RP with Benchmark Open Clusters

The Astrophysical Journal
Recent literature reports a color deviation between observed Gaia color–magnitude diagrams (CMDs) and theoretical model isochrone predictions, particularly in the very low-mass regime.
Fan Wang, Min Fang, Xiaoting Fu, Yang Chen, Lu Li, Xiaoying Pang, Zhongmu Li, Jing Tang, Wenyuan Cui, Haijun Tian, Chao Liu   +10 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Direct Evidence for Stellar Initial Mass Function Variation in the Milky Way

The Astrophysical Journal Letters
Because direct measurements require resolved stellar populations, including low-mass stars, determining the stellar initial mass function (IMF) has been a historically difficult problem even within our own Galaxy, and impossible everywhere else.
Charles L. Steinhardt, Carter Meyerhoff, Alexander J. Luening   +2 more
doaj   +1 more source