Results 91 to 100 of about 5,593,868 (306)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Coronal mass ejections (CMEs) on stars can change the stars’ magnetic field configurations and mass-loss rates during the eruption and propagation and therefore, may affect the stars’ rotation properties on long timescales.
Yu Xu +5 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Mass Ejection Driven by Sudden Energy Deposition in Stellar Envelopes
A number of stellar astrophysical phenomena, such as tidal novae and planetary engulfment, involve sudden injection of subbinding energy in a thin layer within the star, leading to mass ejection of the stellar envelope.
Nicholas J. Corso, Dong Lai
doaj +1 more source
New self-consistent theoretical descriptions for mass-loss rates of O-type stars
Context. Massive O-type stars lose a significant fraction of their mass through radiation-driven winds, a process that critically shapes their evolution and feedback into the interstellar medium.
Figueroa-Tapia F. +7 more
doaj +1 more source
Post-AGB Variables and Stellar Mass-Loss [PDF]
A brief review is given of the various types of star which are thought to be in the immediate post-AGB stage of evolution. The paper then concentrates on the properties of the RCB stars and particularly on the mass-loss process in these stars. It is suggested that grain formation takes place over the cool regions of giant convection cells in a super ...
openaire +1 more source
Modelling the hidden magnetic field of low-mass stars [PDF]
PL acknowledges support from a Science and Technology Facilities Council studentship. JM, AAV and RF acknowledge support from fellowships of the Alexander von Humboldt foundation, the Royal Astronomical Society and Science and Technology Facilities ...
Morin, J. +8 more
core +1 more source
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Mass observation / by Mass Observation.
Electronic reproduction. Canberra, A.C.T.
Mass-Observation.
core
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source

