Results 121 to 130 of about 409,343 (365)
Observations of Extremely Metal-poor O Stars: Weak Winds and Constraints for Evolution Models
The Astrophysical JournalMetal-poor massive stars drive the evolution of low-mass galaxies, both locally and at high redshift. However, quantifying the feedback they impart to their local surroundings remains uncertain because models of stellar evolution, mass loss, and ionizing
O. Grace Telford +5 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Searching for Stellar-feedback-driven Outflow Signatures: A Deep Dive into NGC 3741
The Astrophysical JournalStellar feedback drives winds and outflows critical to the baryon cycles of low-mass galaxies whose shallow gravitational potential wells make them particularly susceptible to mass and metal loss through outflows. However, spatially resolved observations
Lexi N. Gault +7 more
doaj +1 more source
The Cepheid mass discrepancy and pulsation-driven mass loss
, 2011 Context. A longstanding challenge for understanding classical Cepheids is the Cepheid mass discrepancy, where theoretical mass estimates using stellar evolution and stellar pulsation calculations have been found to differ by approximately 10 - 20%. Aims.
Barmby +43 more
core +2 more sources
Post-AGB Variables and Stellar Mass-Loss [PDF]
Symposium - International Astronomical Union, 2000 A brief review is given of the various types of star which are thought to be in the immediate post-AGB stage of evolution. The paper then concentrates on the properties of the RCB stars and particularly on the mass-loss process in these stars. It is suggested that grain formation takes place over the cool regions of giant convection cells in a super ...
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Implications of the metallicity dependence of Wolf-Rayet winds
, 2006 Aims: Recent theoretical predictions for the winds of Wolf-Rayet stars indicate that their mass-loss rates scale with the initial stellar metallicity in the local Universe.We aim to investigate how this predicted dependence affects the models of Wolf ...
Asplund +30 more
core +2 more sources