Results 131 to 140 of about 5,593,868 (306)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Testing the Rossby Paradigm: Weakened Magnetic Braking in Early K-type Stars
The Astrophysical JournalThere is an intricate relationship between the organization of large-scale magnetic fields by a stellar dynamo and the rate of angular momentum loss due to magnetized stellar winds. An essential ingredient for the operation of a large-scale dynamo is the
Travis S. Metcalfe +14 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Coevolution of Nuclear Star Clusters and Massive Black Holes: Extreme-mass-ratio Inspirals
The Astrophysical JournalWe explore extreme-mass-ratio inspirals (EMRIs) in the coevolution of massive black holes (MBHs) and nuclear star clusters (NSCs), which host diverse stellar populations across a wide range of masses. The dynamics are simulated self-consistently with GNC
Fupeng Zhang, Pau Amaro Seoane
doaj +1 more source
On the Relation between Stellar Mass Loss and Luminosity
The Astrophysical Journal, 2000 The prediction of the fluctuation theory of stellar mass loss is shown to be compatible with the principle of minimum entropy production.
openaire +1 more source
, 2013 It was recently suggested that compared to its stellar mass (M-*), the central stellar velocity dispersion (sigma(*)) of a galaxy might be a better indicator for its host dark matter halo mass.
Li, Cheng, Wang, Lixin, Jing, Y. P.
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Stellar mass-loss near the Eddington limit
, 2013 Context. Towards the end of their evolution, hot massive stars develop strong stellar winds and appear as emission line stars, such as Wolf-Rayet (WR) stars or luminous blue variables (LBVs).
J. S. Vink, G. Gräfener
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source