Results 191 to 200 of about 716,854 (348)

The Heavy Metal Survey: Star Formation Constraints and Dynamical Masses of 21 Massive Quiescent Galaxies at z = 1.3–2.3

The Astrophysical Journal
In this paper, we present the Heavy Metal Survey, which obtained ultradeep medium-resolution spectra of 21 massive quiescent galaxies at 1.3 < z < 2.3 with Keck/LRIS and MOSFIRE.
Mariska Kriek, Aliza G. Beverage, Sedona H. Price, Katherine A. Suess, Guillermo Barro, Rachel S. Bezanson, Charlie Conroy, Sam E. Cutler, Marijn Franx, Jamie Lin, Brian Lorenz, Yilun Ma, Ivelina G. Momcheva, Lamiya A. Mowla, Imad Pasha, Pieter van Dokkum, Katherine E. Whitaker   +16 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

JADES + JEMS: A Detailed Look at the Buildup of Central Stellar Cores and Suppression of Star Formation in Galaxies at Redshifts 3 < z < 4.5

The Astrophysical Journal
We present a spatially resolved study of stellar populations in six galaxies with stellar masses M _* ∼ 10 ^10 M _☉ at z ∼ 3.7 using 14-filter James Webb Space Telescope (JWST)/NIRCam imaging from the JADES and JEMS surveys. The six galaxies are visually
Zhiyuan Ji, Christina C. Williams, Sandro Tacchella, Katherine A. Suess, William M. Baker, Stacey Alberts, Andrew J. Bunker, Benjamin D. Johnson, Brant Robertson, Fengwu Sun, Daniel J. Eisenstein, Marcia Rieke, Michael V. Maseda, Kevin Hainline, Ryan Hausen, George Rieke, Christopher N. A. Willmer, Eiichi Egami, Irene Shivaei, Stefano Carniani, Stephane Charlot, Jacopo Chevallard, Emma Curtis-Lake, Tobias J. Looser, Roberto Maiolino, Chris Willott, Zuyi Chen, Jakob M. Helton, Jianwei Lyu, Erica Nelson, Rachana Bhatawdekar, Kristan Boyett, Lester Sandles   +32 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Luminosity and Stellar Mass Functions of Faint Photometric Satellites around Spectroscopic Central Galaxies from DESI Year-1 Bright Galaxy Survey

The Astrophysical Journal
We measure the luminosity functions (LFs) and stellar mass functions (SMFs) of photometric satellite galaxies around spectroscopically identified isolated central galaxies (ICGs). The photometric satellites are from the DESI Legacy Imaging Surveys (DR9),
Wenting Wang, Xiaohu Yang, Yipeng Jing, Ashley J. Ross, Malgorzata Siudek, John Moustakas, Samuel G. Moore, Shaun Cole, Carlos Frenk, Jiaxi Yu, Sergey E. Koposov, Jiaxin Han, Zhenlin Tan, Kun Xu, Yizhou Gu, Yirong Wang, Oleg Y. Gnedin, Jessica Nicole Aguilar, Steven Ahlen, Davide Bianchi, David Brooks, Todd Claybaugh, Axel de la Macorra, Arjun Dey, Peter Doel, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Gaston Gutierrez, Klaus Honscheid, Mustapha Ishak, Theodore Kisner, Martin Landriau, Laurent Le Guillou, Marc Manera, Aaron Meisner, Ramon Miquel, Seshadri Nadathur, Claire Poppett, Francisco Prada, Ignasi Pérez-Ràfols, Graziano Rossi, Eusebio Sanchez, David Schlegel, Hee-Jong Seo, Joseph Harry Silber, David Sprayberry, Gregory Tarlé, Benjamin Alan Weaver, Hu Zou   +49 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

LAMOST Reveals Long-lived Protoplanetary Disks

The Astronomical Journal
While both observations and theories demonstrate that protoplanetary disks are not expected to live much longer than ∼10 Myr, several examples of prolonged disks have been observed in the past.
Xiao-Long Wang, Min Fang, Yao Liu, Miao-Miao Zhang, Wen-Yuan Cui   +4 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source