Results 181 to 190 of about 716,854 (348)

The Outskirt Stellar Mass of Low-redshift Massive Galaxies Is an Excellent Halo Mass Proxy in Illustris/IllustrisTNG Simulations

The Astrophysical Journal
Recent observations suggest that the extended stellar halos of low-redshift massive galaxies are tightly connected to the assembly of their dark matter halos.
Shuo Xu, Song Huang, Alexie Leauthaud, Benedikt Diemer, Katya Leidig, Carlo Cannarozzo, Conghao Zhou   +6 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Dynamical Mass of the Ophiuchus Intermediate-mass Stellar System S1 with DYNAMO-VLBA

The Astronomical Journal
We report dynamical mass measurements of the individual stars in the most luminous and massive stellar member of the nearby Ophiuchus star-forming region, the young tight binary system S1.
Jazmín Ordóñez-Toro, Sergio A. Dzib, Laurent Loinard, Gisela Ortiz-León, Marina A. Kounkel, Josep M. Masqué, S.-N. X. Medina, Phillip A. B. Galli, Trent J. Dupuy, Luis F. Rodríguez, Luis H. Quiroga-Nuñez   +10 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Merger-driven Growth of Intermediate-mass Black Holes: Constraints from Hubble Space Telescope Imaging of Hyper-luminous X-Ray Sources

The Astrophysical Journal
Hyper-luminous X-ray sources (HLXs) are extragalactic off-nuclear X-ray sources with luminosities exceeding the theoretical limit for accretion onto stellar-mass compact objects.
R. Scott Barrows, Mar Mezcua, Julia M. Comerford, Daniel Stern   +3 more
doaj   +1 more source

Extending the Globular Cluster System-Halo Mass Relation to the Lowest Galaxy Masses

, 2018
High mass galaxies, with halo masses $M_{200} \ge 10^{10} M_{\odot}$, reveal a remarkable near-linear relation between their globular cluster (GC) system mass and their host galaxy halo mass.
Collins, Michelle L. M., Forbes, Duncan A., Gieles, Mark, Read, Justin I.   +3 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Discovery and Characterization of Two Ultrafaint Dwarfs outside the Halo of the Milky Way: Leo M and Leo K

The Astrophysical Journal
We report the discovery of two ultrafaint dwarf galaxies, Leo M and Leo K, that lie outside the halo of the Milky Way (MW). Using Hubble Space Telescope imaging of the resolved stars, we create color–magnitude diagrams reaching the oldest main-sequence ...
Kristen. B. W. McQuinn, Yao-Yuan Mao, Erik J. Tollerud, Roger E. Cohen, David Shih, Matthew R. Buckley, Andrew E. Dolphin   +6 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source