Results 111 to 120 of about 46,211 (288)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Inferring Host-galaxy Properties of LIGO–Virgo–KAGRA’s Black Holes
The Astrophysical JournalObservations of gravitational waves from binary black hole (BBH) mergers have measured the redshift evolution of the BBH merger rate. The number density of galaxies in the Universe evolves differently with redshift based on their physical properties ...
Aditya Vijaykumar +3 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Evidence for Evolved Stellar Binary Mergers in Observed B-type Blue Supergiants
The Astrophysical Journal LettersBlue supergiants are the brightest stars in their host galaxies, and yet their evolutionary status has been a long-standing problem in stellar astrophysics.
Athira Menon +10 more
doaj +1 more source
Stellar populations in gas-rich galaxy mergers I. Dependence on star formation history
, 1998 We investigate the nature of stellar populations of major galaxy mergers between late-type spirals considerably abundant in interstellar medium by performing numerical simulations designed to solve both the dynamical and chemical evolution in a self ...
Bekki, Kenji, Shioya, Yasuhiro
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Astrophysical Journal LettersWe investigate the origin of warps in stellar disks using high-resolution Milky Way analogs from the IllustrisTNG50 simulation. Focusing on galaxies that experienced a major merger, we identify a characteristic azimuthal misalignment between the warp ...
Lekshmi Thulasidharan +2 more
doaj +1 more source
Decoding Galactic Merger Histories
Galaxies, 2017 Galaxy mergers are expected to influence galaxy properties, yet measurements of individual merger histories are lacking. Models predict that merger histories can be measured using stellar halos and that these halos can be quantified using observations of
Eric F. Bell +7 more
doaj +1 more source