Results 121 to 130 of about 46,211 (288)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Probing Binary Black Hole Formation Channels through Cosmic Large-scale Structure

The Astrophysical Journal Letters
The growing number of binary black hole mergers detected through gravitational waves offers unprecedented insight into their underlying population, yet their astrophysical formation channels remain unresolved.
William J. Smith, Krystal Ruiz-Rocha, Kelly Holley-Bockelmann, Michela Mapelli, Karan Jani   +4 more
doaj   +1 more source

Merging stellar-mass binary black holes

, 2018
The LIGO and Virgo detectors have recently directly observed gravitational waves from several mergers of pairs of stellar-mass black holes, as well as from one merging pair of neutron stars.
Farmer, Alison, Mandel, Ilya
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

How to Escape from a Trap: Outcomes of Repeated Black Hole Mergers in Active Galactic Nuclei

The Astrophysical Journal Letters
Stellar-mass black holes (BHs) embedded in active galactic nuclei (AGN) may be major sources of astrophysical gravitational waves (GWs), contributing both to the observed LIGO–Virgo–KAGRA population of binary BH mergers and to future populations of LISA ...
Shmuel Gilbaum, Evgeni Grishin, Nicholas C. Stone, Ilya Mandel   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Where Have All the Little Red Dots Gone? Supermassive Black Hole Binary Dynamics and Its Impact on Galaxy Properties

The Astrophysical Journal Letters
Recent James Webb Space Telescope observations have revealed a peculiar class of galaxies at redshifts z  ≳ 6, characterized by extremely high central stellar densities and overmassive central supermassive black holes (SMBHs), “little red dots” (LRDs). A
Fazeel Mahmood Khan, Benjamin L. Davis, Andrea Valerio Macciò, Kelly Holley-Bockelmann   +3 more
doaj   +1 more source

A magnetic massive star has experienced a stellar merger

Science
Massive stars (those ≥8 solar masses at formation) have radiative envelopes that cannot sustain a dynamo, the mechanism that produces magnetic fields in lower-mass stars. Despite this, approximately 7% of massive stars have observed magnetic fields, the origin of which is debated.
A. J. Frost, H. Sana, L. Mahy, G. Wade, J. Barron, J.-B. Le Bouquin, A. Mérand, F. R. N. Schneider, T. Shenar, R. H. Barbá, D. M. Bowman, M. Fabry, A. Farhang, P. Marchant, N. I. Morrell, J. V. Smoker   +15 more
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source