Results 131 to 140 of about 46,211 (288)

Stellar streams around dwarf galaxies in the local Universe

Astronomy & Astrophysics
Context. While mergers between massive galaxies and their dwarf satellites have been well studied, the properties of dwarf–dwarf satellite mergers are not well constrained.
Sakowska Joanna D., Martínez-Delgado David, Pearson Sarah, Riquel-Castilla Francisco J., Starkenburg Tjitske K., Donatiello Giuseppe, Deason Alis, Erkal Denis, Taylor Ethan D.   +8 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Study of the Merging Dwarf Galaxy VCC322

The Astrophysical Journal
Galaxy interactions and mergers can enhance or reduce star formation, but a complete understanding of the involved processes is still lacking. The effect of dwarf galaxy mergers is even less clear than their massive counterpart.
Lan-Yue Zhang, Yinghe Zhao, Hong-Xin Zhang   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

GW231123: Likely a Product of Successive Mergers from ∼10 Stellar-mass Black Holes

The Astrophysical Journal
GW231123 is an exceptionally massive binary black hole (BBH) merger with unusually high component spins. Such extreme properties challenge conventional stellar evolution models, predicting a black hole (BH) mass gap due to pair-instability supernovae. We
Yin-Jie Li, Shao-Peng Tang, Ling-Qin Xue, Yi-Zhong Fan   +3 more
doaj   +1 more source

Stellar Collisions and Mergers in the Galactic Center

, 2000
Stars are most likely to merge or collide in regions of the highest stellar densities, and our own Galactic Center contains many stars packed into a relatively small volume -- even the ambient stellar number density in the central 50 pc is quite high, ~10^3 stars pc^{-3}.
Figer, Donald F., Kim, Sungsoo S.
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

MAGICS. II. Seed Black Holes Stripped of Their Surrounding Stars Do Not Sink

The Astrophysical Journal
Massive black hole (MBH) seed mergers are expected to be among the loudest sources of gravitational waves detected by the Laser Interferometer Space Antenna, providing a unique window into the birth and early growth of MBHs.
Yihao Zhou, Diptajyoti Mukherjee, Nianyi Chen, Tiziana Di Matteo, Peter H. Johansson, Antti Rantala, Christian Partmann, Ugo Niccolò Di Carlo, Simeon Bird, Yueying Ni   +9 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source