Results 61 to 70 of about 3,346 (262)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

New Theoretical Instability Regions, Period–Luminosity Relations, and Masses for Blue Large-amplitude Pulsators

The Astrophysical Journal
Blue large-amplitude pulsators (BLAPs) are a recently discovered group of hot pulsating stars whose evolutionary status remains uncertain. Their proposed progenitors are either ≃0.3 M _⊙ shell H-burning stars or ≃1.0 M _⊙ core He-burning stars, both ...
Susmita Das, Daniel Jadlovský, László Molnár   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The DREAMS Project: Disentangling the Impact of Halo-to-halo Variance and Baryonic Feedback on Milky Way Satellite Galaxies

The Astrophysical Journal
We analyze the properties of satellite galaxies around 1024 Milky Way–mass hosts from the DREAMS Project, simulated within a ΛCDM cosmology. Utilizing the TNG galaxy-formation model, the DREAMS simulations incorporate both baryonic physics and ...
Jonah C. Rose, Mariangela Lisanti, Paul Torrey, Francisco Villaescusa- Navarro, Alex M. Garcia, Arya Farahi, Carrie Filion, Alyson M. Brooks, Nitya Kallivayalil, Kassidy E. Kollmann, Ethan Lilie, Jiaxuan Li, Olivia Mostow, Akaxia Cruz, Tri Nguyen, Sandip Roy, Andrew B. Pace, Niusha Ahvazi, Stephanie O’Neil, Xuejian Shen, Francis-Yan Cyr-Racine, Adrian M. Price-Whelan, Marla Geha, Lina Necib, Mark Vogelsberger, Julian B. Muñoz, Julianne J. Dalcanton   +26 more
doaj   +1 more source

The µ Herculis system solved after nearly three centuries

Astronomy & Astrophysics
Context. µ Herculis is a bright, nearby quadruple system. Its brightest member, µ Her Aa, displays solar-like oscillations, establishing the system as a crucial benchmark for asteroseismology, provided that its mass can be determined independently of ...
Marcussen Marcus L., Lund Mikkel N., Grundahl Frank, Huber Daniel, Knudstrup Emil, Kraus Adam L., Baranec Christoph, Pallé Pere L., Dupuy Trent J., Huber Guillaume, Ou James, Werber Zach, Zhang Ruihan, Riddle Reed   +13 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

MESA Isochrones and Stellar Tracks (MIST). III. The White Dwarf Cooling Sequence

The Astrophysical Journal Supplement Series
We present a substantial update to the MESA Isochrones and Stellar Tracks (MIST) library, extending the MIST model grids and isochrones down the white dwarf (WD) cooling sequence with realistic physics for WD cooling timescales.
Evan B. Bauer, Aaron Dotter, Charlie Conroy, Tim Cunningham, Minjung Park, Pier-Emmanuel Tremblay   +5 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source