Results 81 to 90 of about 197,789 (295)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Flexible Stellarator Physics Facility

We propose to build a Flexible Stellarator Physics Facility to explore promising regions of the vast parameter space of disruption-free stellarator solutions for Fusion Pilot Plants (FPPs).
Parra, F. I., Baek, S. -G., Churchill, M., Demers, D. R., Dudson, B., Ferraro, N. M., Geiger, B., Gerhardt, S., Hammond, K. C., Hudson, S., Jorge, R., Kolemen, E., Kriete, D. M., Kumar, S. T. A., Landreman, M., Lowe, C., Maurer, D. A., Nespoli, F., Pablant, N., Pueschel, M. J., Punjabi, A., Schwartz, J. A., Swanson, C. P. S., Wright, A. M.   +23 more
openaire   +3 more sources

MESA Isochrones and Stellar Tracks (MIST). III. The White Dwarf Cooling Sequence

The Astrophysical Journal Supplement Series
We present a substantial update to the MESA Isochrones and Stellar Tracks (MIST) library, extending the MIST model grids and isochrones down the white dwarf (WD) cooling sequence with realistic physics for WD cooling timescales.
Evan B. Bauer, Aaron Dotter, Charlie Conroy, Tim Cunningham, Minjung Park, Pier-Emmanuel Tremblay   +5 more
doaj   +1 more source

Physics of Rotation in Stellar Models [PDF]

, 2009
32 pages, 7 figures, lectures, CNRS school, will be published by ...
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Stellar turbulence and mode physics [PDF]

Astrophysics and Space Science, 2009
An overview of selected topical problems on modelling oscillation properties in solar-like stars is presented. High-quality oscillation data from both space-borne intensity observations and ground-based spectroscopic measurements provide first tests of the still-ill-understood, superficial layers in distant stars.
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Boron Abundances in Early B Dwarfs of the Galactic Open Cluster NGC 3293

The Astrophysical Journal
New boron abundances or upper limits have been determined for eight early B stars in the young Galactic open cluster NGC 3293, using UV spectra obtained by the Hubble Space Telescope Cosmic Origins Spectrograph.
Charles R. Proffitt, Harim Jin, Simone Daflon, Daniel J. Lennon, Norbert Langer, Katia Cunha, Talawanda Monroe   +6 more
doaj   +1 more source

Introduction to nuclear astrophysics

, 2009
In the first lecture of this volume, we will present the basic fundamental ideas regarding nuclear processes occurring in stars. We start from stellar observations, will then elaborate on some important quantum-mechanical phenomena governing nuclear ...
Iliadis, Christian
core   +1 more source