Results 81 to 90 of about 3,346 (262)

Pulsation models of O-rich and C-rich long period variables

EPJ Web of Conferences, 2017
The intrinsic variability of luminous red giants is an observable providing important information about stellar structure and evolution. Our aim is to provide a solid theoretical background to the wide amount of data coming from present and future ...
Trabucchi Michele, Marigo Paola, Montalbán Josefina, Wood Peter R., Girardi Léo   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Lux: A Generative, Multioutput, Latent-variable Model for Astronomical Data with Noisy Labels

The Astronomical Journal
The large volume of spectroscopic data available now and from near-future surveys will enable high-dimensional measurements of stellar parameters and properties. Current methods for determining stellar labels from spectra use physics-driven models, which
Danny Horta, Adrian M. Price-Whelan, David W. Hogg, Melissa K. Ness, Andrew R. Casey   +4 more
doaj   +1 more source

Observational clues to the physics at the magnetosphere in young stellar objects

EPJ Web of Conferences, 2014
Classical T Tauri stars offer an excellent laboratory to study the accretion process and star-disk interaction, which define the transfer of mass and angular momentum in the system. The interaction takes place very close to the star, in a region of about
Alencar Silvia H. P.
doaj   +1 more source

Physics of Stellar Coronae

, 2009
Stellar coronae, defined by the ensemble of magnetic field structures above stellar photospheres and chromospheres together with their thermal or non-thermal plasma content, play an important role in our understanding of stellar magnetic fields, the stellar magnetic dynamo, and interactions between a star and its environment.
openaire   +2 more sources

Stellarator physics evaluation studies

, 1983
Stellarator/torsatron configurations with a wide range of parameters have been evaluated and compared in terms of their vacuum field topology, magnetohydrodynamic equilibrium and stability, and guiding center orbit confinement. The torsatron configurations are found to be the most suitable choice for a near-term physics experiment.
B. A. Carreras, J. H. Harris, J. A. Rome
openaire   +2 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source